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The novel multi-target iron chelator, M30 modulates HIF-1α-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP/PS1 Alzheimer's disease mice.
Mechlovich D, Amit T, Bar-Am O, Mandel S, Youdim MB, Weinreb O. Mechlovich D, et al. Among authors: weinreb o. Curr Alzheimer Res. 2014 Feb;11(2):119-27. doi: 10.2174/1567205010666131212112529. Curr Alzheimer Res. 2014. PMID: 24359498
We report that chronic treatment with M30 (1 and 5 mg/kg p.o; three times a week for 9 months) significantly elevated cortical insulin and InsR transcript and protein expression, respectively and increased the phosphorylated form of glycogen synthase kinase-3β in the front …
We report that chronic treatment with M30 (1 and 5 mg/kg p.o; three times a week for 9 months) significantly elevated cortical insuli …
Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases.
Mandel SA, Amit T, Weinreb O, Reznichenko L, Youdim MB. Mandel SA, et al. Among authors: weinreb o. CNS Neurosci Ther. 2008 Winter;14(4):352-65. doi: 10.1111/j.1755-5949.2008.00060.x. CNS Neurosci Ther. 2008. PMID: 19040558 Free PMC article. Review.
Molecular targets of the multifunctional iron-chelating drug, M30, in the brains of mouse models of type 2 diabetes mellitus.
Mechlovich D, Amit T, Bar-Am O, Weinreb O, Youdim MB. Mechlovich D, et al. Among authors: weinreb o. Br J Pharmacol. 2014 Dec;171(24):5636-49. doi: 10.1111/bph.12862. Br J Pharmacol. 2014. PMID: 25073425 Free PMC article.
The novel multitarget iron chelating and propargylamine drug M30 affects APP regulation and processing activities in Alzheimer's disease models.
Amit T, Bar-Am O, Mechlovich D, Kupershmidt L, Youdim MBH, Weinreb O. Amit T, et al. Among authors: weinreb o. Neuropharmacology. 2017 Sep 1;123:359-367. doi: 10.1016/j.neuropharm.2017.05.026. Epub 2017 May 29. Neuropharmacology. 2017. PMID: 28571715 Review.
Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism.
Pollak Y, Mechlovich D, Amit T, Bar-Am O, Manov I, Mandel SA, Weinreb O, Meyron-Holtz EG, Iancu TC, Youdim MB. Pollak Y, et al. Among authors: weinreb o. J Neural Transm (Vienna). 2013 Jan;120(1):37-48. doi: 10.1007/s00702-012-0795-x. Epub 2012 Mar 25. J Neural Transm (Vienna). 2013. PMID: 22446839
In vivo studies demonstrated that M30 administration (1 mg/kg, P.O. three times a week) reduced hepatic ferritin levels; increased hepatic insulin receptor and glucose transporter-1 levels and improved glucose tolerance in C57BL/6 mice and in a mouse model of type-2 diabet …
In vivo studies demonstrated that M30 administration (1 mg/kg, P.O. three times a week) reduced hepatic ferritin levels; increased he …
Multi-target, neuroprotective and neurorestorative M30 improves cognitive impairment and reduces Alzheimer's-like neuropathology and age-related alterations in mice.
Kupershmidt L, Amit T, Bar-Am O, Weinreb O, Youdim MB. Kupershmidt L, et al. Among authors: weinreb o. Mol Neurobiol. 2012 Aug;46(1):217-20. doi: 10.1007/s12035-012-8304-7. Epub 2012 Jul 31. Mol Neurobiol. 2012. PMID: 22847630
Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis.
Golko-Perez S, Mandel S, Amit T, Kupershmidt L, Youdim MB, Weinreb O. Golko-Perez S, et al. Among authors: weinreb o. Neurotox Res. 2016 Feb;29(2):208-17. doi: 10.1007/s12640-015-9574-4. Epub 2015 Nov 18. Neurotox Res. 2016. PMID: 26581376
Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and β-amyloid in ageing and Alzheimer's disease.
Weinreb O, Amit T, Bar-Am O, Youdim MB. Weinreb O, et al. Br J Pharmacol. 2016 Jul;173(13):2080-94. doi: 10.1111/bph.13318. Epub 2015 Dec 1. Br J Pharmacol. 2016. PMID: 26332830 Free PMC article. Review.
Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging.
Bar-Am O, Amit T, Kupershmidt L, Aluf Y, Mechlovich D, Kabha H, Danovitch L, Zurawski VR, Youdim MB, Weinreb O. Bar-Am O, et al. Among authors: weinreb o. Neurobiol Aging. 2015 Mar;36(3):1529-42. doi: 10.1016/j.neurobiolaging.2014.10.026. Epub 2014 Oct 22. Neurobiol Aging. 2015. PMID: 25499799
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