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Structure of importin-beta bound to the IBB domain of importin-alpha.
Cingolani G, Petosa C, Weis K, Müller CW. Cingolani G, et al. Nature. 1999 May 20;399(6733):221-9. doi: 10.1038/20367. Nature. 1999. PMID: 10353244
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export.
Montpetit B, Thomsen ND, Helmke KJ, Seeliger MA, Berger JM, Weis K. Montpetit B, et al. Nature. 2011 Apr 14;472(7342):238-42. doi: 10.1038/nature09862. Epub 2011 Mar 27. Nature. 2011. PMID: 21441902 Free PMC article.
Challenges facing the biologist doing chemical genetics.
Soderholm J, Uehara-Bingen M, Weis K, Heald R. Soderholm J, et al. Nat Chem Biol. 2006 Feb;2(2):55-8. doi: 10.1038/nchembio0206-55. Nat Chem Biol. 2006. PMID: 16421579
Analysis of a RanGTP-regulated gradient in mitotic somatic cells.
Kaláb P, Pralle A, Isacoff EY, Heald R, Weis K. Kaláb P, et al. Nature. 2006 Mar 30;440(7084):697-701. doi: 10.1038/nature04589. Nature. 2006. PMID: 16572176
Structure of the C-terminus of the mRNA export factor Dbp5 reveals the interaction surface for the ATPase activator Gle1.
Dossani ZY, Weirich CS, Erzberger JP, Berger JM, Weis K. Dossani ZY, et al. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16251-6. doi: 10.1073/pnas.0902251106. Epub 2009 Sep 2. Proc Natl Acad Sci U S A. 2009. PMID: 19805289 Free PMC article.
Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export.
Weirich CS, Erzberger JP, Flick JS, Berger JM, Thorner J, Weis K. Weirich CS, et al. Nat Cell Biol. 2006 Jul;8(7):668-76. doi: 10.1038/ncb1424. Epub 2006 Jun 18. Nat Cell Biol. 2006. PMID: 16783364
Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking.
Lowe AR, Siegel JJ, Kalab P, Siu M, Weis K, Liphardt JT. Lowe AR, et al. Nature. 2010 Sep 30;467(7315):600-3. doi: 10.1038/nature09285. Epub 2010 Sep 1. Nature. 2010. PMID: 20811366 Free PMC article.
Importazole, a small molecule inhibitor of the transport receptor importin-β.
Soderholm JF, Bird SL, Kalab P, Sampathkumar Y, Hasegawa K, Uehara-Bingen M, Weis K, Heald R. Soderholm JF, et al. ACS Chem Biol. 2011 Jul 15;6(7):700-8. doi: 10.1021/cb2000296. Epub 2011 Apr 21. ACS Chem Biol. 2011. PMID: 21469738 Free PMC article.
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