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Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure.
Bristol JA, Sircar I, Moos WH, Evans DB, Weishaar RE. Bristol JA, et al. J Med Chem. 1984 Sep;27(9):1099-101. doi: 10.1021/jm00375a001. J Med Chem. 1984. PMID: 6471063 No abstract available.
Cardiotonic agents. 5. 1,2-Dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-6-methyl-2-oxo-3- pyridinecarbonitriles and related compounds. Synthesis and inotropic activity.
Sircar I, Duell BL, Bristol JA, Weishaar RE, Evans DB. Sircar I, et al. J Med Chem. 1987 Jun;30(6):1023-9. doi: 10.1021/jm00389a011. J Med Chem. 1987. PMID: 3585900
Cardiotonic agents. 6. Synthesis and inotropic activity of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones: ring-contracted analogues of imazodan (CI-914).
Sircar I, Morrison GC, Burke SE, Skeean R, Weishaar RE. Sircar I, et al. J Med Chem. 1987 Oct;30(10):1724-8. doi: 10.1021/jm00393a007. J Med Chem. 1987. PMID: 3656349
Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Isolation, characterization, and effects of various reference phosphodiesterase inhibitors and cardiotonic agents.
Weishaar RE, Burrows SD, Kobylarz DC, Quade MM, Evans DB. Weishaar RE, et al. Biochem Pharmacol. 1986 Mar 1;35(5):787-800. doi: 10.1016/0006-2952(86)90247-9. Biochem Pharmacol. 1986. PMID: 3006691
Studies aimed at elucidating the mechanism of action of CI-914, a new cardiotonic agent.
Weishaar RE, Quade M, Schenden JA, Boyd DK, Evans DB. Weishaar RE, et al. Eur J Pharmacol. 1985 Dec 17;119(3):205-15. doi: 10.1016/0014-2999(85)90297-3. Eur J Pharmacol. 1985. PMID: 3004993
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