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Jurkat T cells and development of the T-cell receptor signalling paradigm.
Abraham RT, Weiss A. Abraham RT, et al. Among authors: weiss a. Nat Rev Immunol. 2004 Apr;4(4):301-8. doi: 10.1038/nri1330. Nat Rev Immunol. 2004. PMID: 15057788 Review. No abstract available.
CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation.
Fraser JD, Newton ME, Weiss A. Fraser JD, et al. Among authors: weiss a. J Exp Med. 1992 Apr 1;175(4):1131-4. doi: 10.1084/jem.175.4.1131. J Exp Med. 1992. PMID: 1313075 Free PMC article.
Interaction of the T cell antigen receptor (TCR) with antigen in the context of major histocompatibility molecules mediates signal transduction, but T cell activation appears to require the induction of a second costimulatory signal transduction pathway. Recent studies sug …
Interaction of the T cell antigen receptor (TCR) with antigen in the context of major histocompatibility molecules mediates signal transduct …
Regulation of protein tyrosine kinase activation by the T-cell antigen receptor zeta chain.
Weiss A, Chan AC, Iwashima M, Straus D, Irving BA. Weiss A, et al. Cold Spring Harb Symp Quant Biol. 1992;57:107-16. doi: 10.1101/sqb.1992.057.01.014. Cold Spring Harb Symp Quant Biol. 1992. PMID: 1339649 No abstract available.
Restoration of T cell receptor-mediated signal transduction by transfection of CD45 cDNA into a CD45-deficient variant of the Jurkat T cell line.
Koretzky GA, Kohmetscher MA, Kadleck T, Weiss A. Koretzky GA, et al. Among authors: weiss a. J Immunol. 1992 Aug 15;149(4):1138-42. J Immunol. 1992. PMID: 1380033
Evidence suggests ligation of the TCR induces activation of a PTK that may be a member of the src family. One early consequence of this TCR-mediated PTK activation is the phosphorylation of the gamma 1 isoform of phospholipase C. ...We demonstrate that reconstitutio …
Evidence suggests ligation of the TCR induces activation of a PTK that may be a member of the src family. One early consequenc …
New insights into T-cell antigen receptor structure and signal transduction.
Chan AC, Irving BA, Weiss A. Chan AC, et al. Among authors: weiss a. Curr Opin Immunol. 1992 Jun;4(3):246-51. doi: 10.1016/0952-7915(92)90072-m. Curr Opin Immunol. 1992. PMID: 1418701 Review.
The protein tyrosine kinase inhibitor herbimycin A, but not genistein, specifically inhibits signal transduction by the T cell antigen receptor.
Graber M, June CH, Samelson LE, Weiss A. Graber M, et al. Among authors: weiss a. Int Immunol. 1992 Nov;4(11):1201-10. doi: 10.1093/intimm/4.11.1201. Int Immunol. 1992. PMID: 1472473
Herbimycin A did not inhibit activation of PLC by HM1. Genistein had a much less pronounced effect than herbimycin A on the appearance of tyrosine phosphoproteins. ...Herbimycin A was not cytotoxic. These findings confirm the role of a regulator …
Herbimycin A did not inhibit activation of PLC by HM1. Genistein had a much less pronounced effect than herbimycin A on …
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor.
Straus DB, Weiss A. Straus DB, et al. Among authors: weiss a. Cell. 1992 Aug 21;70(4):585-93. doi: 10.1016/0092-8674(92)90428-f. Cell. 1992. PMID: 1505025
Analysis of one of these mutants, JCaM1, which is defective in the induction of tyrosine phosphorylation, revealed a defect in the expression of functional lck tyrosine kinase. The lack of lck activity was caused in part by a splicing defect. Expression of the lck c …
Analysis of one of these mutants, JCaM1, which is defective in the induction of tyrosine phosphorylation, revealed a defect in the ex …
Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs.
Margolis B, Hu P, Katzav S, Li W, Oliver JM, Ullrich A, Weiss A, Schlessinger J. Margolis B, et al. Among authors: weiss a. Nature. 1992 Mar 5;356(6364):71-4. doi: 10.1038/356071a0. Nature. 1992. PMID: 1531699
The proto-oncogene vav is expressed in haematopoietic cells and its product Vav contains sequence motifs commonly found in transcription factors, such as helix-loop-helix, leucine-zipper and zinc-finger motifs and nuclear localization signals, as well as a single SH2 and t …
The proto-oncogene vav is expressed in haematopoietic cells and its product Vav contains sequence motifs commonly found in transcription fac …
The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways.
Irving BA, Weiss A. Irving BA, et al. Among authors: weiss a. Cell. 1991 Mar 8;64(5):891-901. doi: 10.1016/0092-8674(91)90314-o. Cell. 1991. PMID: 1705867
To examine the role of the CD3 zeta chain in TCR-mediated signal transduction, a chimeric protein linking the extracellular and transmembrane domains of CD8 to the cytoplasmic domain of the zeta chain was constructed. ...
To examine the role of the CD3 zeta chain in TCR-mediated signal transduction, a chimeric protein linking the extracellular and trans …
Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.
Weiss A, Koretzky G, Schatzman RC, Kadlecek T. Weiss A, et al. Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5484-8. doi: 10.1073/pnas.88.13.5484. Proc Natl Acad Sci U S A. 1991. PMID: 1712101 Free PMC article.
Stimulation of the T-cell antigen receptor (TCR), which itself is not a protein-tyrosine kinase (PTK), activates a PTK and phospholipase C (PLC). ...Since other studies have implicated two members of the src family of PTKs in TCR-mediated signal transduction, our fi …
Stimulation of the T-cell antigen receptor (TCR), which itself is not a protein-tyrosine kinase (PTK), activates a PTK and pho …
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