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The Syk family of protein tyrosine kinases in T-cell activation and development.
Chu DH, Morita CT, Weiss A. Chu DH, et al. Immunol Rev. 1998 Oct;165:167-80. doi: 10.1111/j.1600-065x.1998.tb01238.x. Immunol Rev. 1998. PMID: 9850860 Review.
CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation.
Fraser JD, Newton ME, Weiss A. Fraser JD, et al. J Exp Med. 1992 Apr 1;175(4):1131-4. doi: 10.1084/jem.175.4.1131. J Exp Med. 1992. PMID: 1313075 Free PMC article.
Interaction of the T cell antigen receptor (TCR) with antigen in the context of major histocompatibility molecules mediates signal transduction, but T cell activation appears to require the induction of a second costimulatory signal transduction pathway. Recent studies sug …
Interaction of the T cell antigen receptor (TCR) with antigen in the context of major histocompatibility molecules mediates signal transduct …
Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28.
Fraser JD, Weiss A. Fraser JD, et al. Mol Cell Biol. 1992 Oct;12(10):4357-63. doi: 10.1128/mcb.12.10.4357. Mol Cell Biol. 1992. PMID: 1328852 Free PMC article.
CD28 is a T-cell differentiation antigen that can generate intracellular signals that synergize with those of the TCR to increase T-cell activation and interleukin-2 (IL-2) gene expression. ...As previously demonstrated for the IL-2 promoter, the IL-3 and GM-CSF promoters …
CD28 is a T-cell differentiation antigen that can generate intracellular signals that synergize with those of the TCR to increase T-c …
Regulation of protein tyrosine kinase activation by the T-cell antigen receptor zeta chain.
Weiss A, Chan AC, Iwashima M, Straus D, Irving BA. Weiss A, et al. Cold Spring Harb Symp Quant Biol. 1992;57:107-16. doi: 10.1101/sqb.1992.057.01.014. Cold Spring Harb Symp Quant Biol. 1992. PMID: 1339649 No abstract available.
New insights into T-cell antigen receptor structure and signal transduction.
Chan AC, Irving BA, Weiss A. Chan AC, et al. Curr Opin Immunol. 1992 Jun;4(3):246-51. doi: 10.1016/0952-7915(92)90072-m. Curr Opin Immunol. 1992. PMID: 1418701 Review.
ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.
Chan AC, Iwashima M, Turck CW, Weiss A. Chan AC, et al. Cell. 1992 Nov 13;71(4):649-62. doi: 10.1016/0092-8674(92)90598-7. Cell. 1992. PMID: 1423621
We have recently identified a 70 kd tyrosine phosphoprotein (ZAP-70) that associates with zeta and undergoes tyrosine phosphorylation following TCR stimulation. Here we report the isolation of a cDNA clone encoding ZAP-70. ZAP-70 represents a novel PTK and is …
We have recently identified a 70 kd tyrosine phosphoprotein (ZAP-70) that associates with zeta and undergoes tyrosine phosphorylation …
The protein tyrosine kinase inhibitor herbimycin A, but not genistein, specifically inhibits signal transduction by the T cell antigen receptor.
Graber M, June CH, Samelson LE, Weiss A. Graber M, et al. Int Immunol. 1992 Nov;4(11):1201-10. doi: 10.1093/intimm/4.11.1201. Int Immunol. 1992. PMID: 1472473
Herbimycin A did not inhibit activation of PLC by HM1. Genistein had a much less pronounced effect than herbimycin A on the appearance of tyrosine phosphoproteins. ...Herbimycin A was not cytotoxic. These findings confirm the role of a regulator …
Herbimycin A did not inhibit activation of PLC by HM1. Genistein had a much less pronounced effect than herbimycin A on …
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor.
Straus DB, Weiss A. Straus DB, et al. Cell. 1992 Aug 21;70(4):585-93. doi: 10.1016/0092-8674(92)90428-f. Cell. 1992. PMID: 1505025
Analysis of one of these mutants, JCaM1, which is defective in the induction of tyrosine phosphorylation, revealed a defect in the expression of functional lck tyrosine kinase. The lack of lck activity was caused in part by a splicing defect. Expression of the lck c …
Analysis of one of these mutants, JCaM1, which is defective in the induction of tyrosine phosphorylation, revealed a defect in the ex …
Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.
Koretzky GA, Picus J, Schultz T, Weiss A. Koretzky GA, et al. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2037-41. doi: 10.1073/pnas.88.6.2037. Proc Natl Acad Sci U S A. 1991. PMID: 1672451 Free PMC article.
CD45, a hematopoietic cell-specific surface antigen, has recently been shown to be a protein tyrosine phosphatase. Expression of CD45 is essential for the T-cell antigen receptor to couple with the phosphatidylinositol second messenger pathway and for antigen-mediat …
CD45, a hematopoietic cell-specific surface antigen, has recently been shown to be a protein tyrosine phosphatase. Expression …
The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways.
Irving BA, Weiss A. Irving BA, et al. Cell. 1991 Mar 8;64(5):891-901. doi: 10.1016/0092-8674(91)90314-o. Cell. 1991. PMID: 1705867
To examine the role of the CD3 zeta chain in TCR-mediated signal transduction, a chimeric protein linking the extracellular and transmembrane domains of CD8 to the cytoplasmic domain of the zeta chain was constructed. ...
To examine the role of the CD3 zeta chain in TCR-mediated signal transduction, a chimeric protein linking the extracellular and trans …
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