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Cas9-dependent endogenous gene regulation is required for bacterial virulence.
Sampson TR, Weiss DS. Sampson TR, et al. Biochem Soc Trans. 2013 Dec;41(6):1407-11. doi: 10.1042/BST20130163. Biochem Soc Trans. 2013. PMID: 24256228 Review.
A CRISPR/Cas system mediates bacterial innate immune evasion and virulence.
Sampson TR, Saroj SD, Llewellyn AC, Tzeng YL, Weiss DS. Sampson TR, et al. Nature. 2013 May 9;497(7448):254-7. doi: 10.1038/nature12048. Epub 2013 Apr 14. Nature. 2013. PMID: 23584588 Free PMC article.
In vivo negative selection screen identifies genes required for Francisella virulence.
Weiss DS, Brotcke A, Henry T, Margolis JJ, Chan K, Monack DM. Weiss DS, et al. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):6037-42. doi: 10.1073/pnas.0609675104. Epub 2007 Mar 26. Proc Natl Acad Sci U S A. 2007. PMID: 17389372 Free PMC article.
Repression of bacterial lipoprotein production by Francisella novicida facilitates evasion of innate immune recognition.
Jones CL, Sampson TR, Nakaya HI, Pulendran B, Weiss DS. Jones CL, et al. Cell Microbiol. 2012 Oct;14(10):1531-43. doi: 10.1111/j.1462-5822.2012.01816.x. Epub 2012 Jun 12. Cell Microbiol. 2012. PMID: 22632124 Free PMC article.
Identification of MglA-regulated genes reveals novel virulence factors in Francisella tularensis.
Brotcke A, Weiss DS, Kim CC, Chain P, Malfatti S, Garcia E, Monack DM. Brotcke A, et al. Infect Immun. 2006 Dec;74(12):6642-55. doi: 10.1128/IAI.01250-06. Epub 2006 Sep 25. Infect Immun. 2006. PMID: 17000729 Free PMC article.
Surface sensing in Vibrio parahaemolyticus triggers a programme of gene expression that promotes colonization and virulence.
Gode-Potratz CJ, Kustusch RJ, Breheny PJ, Weiss DS, McCarter LL. Gode-Potratz CJ, et al. Mol Microbiol. 2011 Jan;79(1):240-63. doi: 10.1111/j.1365-2958.2010.07445.x. Epub 2010 Nov 16. Mol Microbiol. 2011. PMID: 21166906 Free PMC article.
The Atypical Occurrence of Two Biotin Protein Ligases in Francisella novicida Is Due to Distinct Roles in Virulence and Biotin Metabolism.
Feng Y, Chin CY, Chakravartty V, Gao R, Crispell EK, Weiss DS, Cronan JE. Feng Y, et al. mBio. 2015 Jun 9;6(3):e00591. doi: 10.1128/mBio.00591-15. mBio. 2015. PMID: 26060274 Free PMC article.
A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion.
Sampson TR, Napier BA, Schroeder MR, Louwen R, Zhao J, Chin CY, Ratner HK, Llewellyn AC, Jones CL, Laroui H, Merlin D, Zhou P, Endtz HP, Weiss DS. Sampson TR, et al. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11163-8. doi: 10.1073/pnas.1323025111. Epub 2014 Jul 14. Proc Natl Acad Sci U S A. 2014. PMID: 25024199 Free PMC article.
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