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Bone marrow transplantation as a strategy for tolerance induction in the clinic.
Pree I, Pilat N, Wekerle T. Pree I, et al. Front Biosci (Landmark Ed). 2009 Jan 1;14:611-20. doi: 10.2741/3267. Front Biosci (Landmark Ed). 2009. PMID: 19273089 Review.
Induction of alloantigen-specific hyporesponsiveness in vitro by n-butyrate: antagonistic effect of cyclosporin A.
Böhmig GA, Wekerle T, Säemann MD, Kovarik J, Zlabinger GJ. Böhmig GA, et al. Transpl Int. 1996;9 Suppl 1:S318-22. doi: 10.1007/978-3-662-00818-8_79. Transpl Int. 1996. PMID: 8959855
Whereas in primary culture, CyA additively enhanced inhibition of DNA synthesis by n-butyrate, the effect of this agent on secondary T cell reactivity was clearly antagonized by CyA. ...Our in vitro finding indicates that specific downregulation of T cell alloreacti …
Whereas in primary culture, CyA additively enhanced inhibition of DNA synthesis by n-butyrate, the effect of this agent on secondary T
Separate regulation of peripheral hematopoietic and thymic engraftment.
Sykes M, Szot GL, Swenson K, Pearson DA, Wekerle T. Sykes M, et al. Exp Hematol. 1998 Jun;26(6):457-65. Exp Hematol. 1998. PMID: 9620278
However, the initial (2-4 weeks posttransplantation) percentages of T and B lymphocytes of donor origin were markedly lower than those of myeloid lineages. ...In contrast, long-term donor representation in the T cell lineage was much lower than in the B cell or myel …
However, the initial (2-4 weeks posttransplantation) percentages of T and B lymphocytes of donor origin were markedly lower than thos …
Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance.
Wekerle T, Sayegh MH, Hill J, Zhao Y, Chandraker A, Swenson KG, Zhao G, Sykes M. Wekerle T, et al. J Exp Med. 1998 Jun 15;187(12):2037-44. doi: 10.1084/jem.187.12.2037. J Exp Med. 1998. PMID: 9625763 Free PMC article.
Progressive deletion of donor-reactive host T cells occurred among peripheral CD4(+) lymphocytes, beginning as early as 1 wk after bone marrow transplantation. ...Central intrathymic deletion of newly developing T cells ensued after donor stem cell engraftment had o …
Progressive deletion of donor-reactive host T cells occurred among peripheral CD4(+) lymphocytes, beginning as early as 1 wk after bo …
Hematopoietic chimerism and tolerance of T cells, B cells, and NK cells.
Sykes M, Ohdan H, Manilay JO, Wekerle T, Yang YG. Sykes M, et al. Transplant Proc. 1998 Dec;30(8):4020. doi: 10.1016/s0041-1345(98)01325-6. Transplant Proc. 1998. PMID: 9865282 No abstract available.
Role of peripheral clonal deletion in tolerance induction with bone marrow transplantation and costimulatory blockade.
Wekerle T, Sayegh MH, Chandraker A, Swenson KG, Zhao Y, Sykes M. Wekerle T, et al. Transplant Proc. 1999 Feb-Mar;31(1-2):680. doi: 10.1016/s0041-1345(98)01605-4. Transplant Proc. 1999. PMID: 10083292 No abstract available.
Mixed chimerism as an approach for the induction of transplantation tolerance.
Wekerle T, Sykes M. Wekerle T, et al. Transplantation. 1999 Aug 27;68(4):459-67. doi: 10.1097/00007890-199908270-00001. Transplantation. 1999. PMID: 10480398 Review. No abstract available.
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