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Ligation of CD28 stimulates the formation of a multimeric signaling complex involving grb-2-associated binder 2 (gab2), SRC homology phosphatase-2, and phosphatidylinositol 3-kinase: evidence that negative regulation of CD28 signaling requires the gab2 pleckstrin homology domain.
Parry RV, Whittaker GC, Sims M, Edmead CE, Welham MJ, Ward SG. Parry RV, et al. Among authors: welham mj. J Immunol. 2006 Jan 1;176(1):594-602. doi: 10.4049/jimmunol.176.1.594. J Immunol. 2006. PMID: 16365455
The PI3K inhibitor arsenal: choose your weapon!
Crabbe T, Welham MJ, Ward SG. Crabbe T, et al. Trends Biochem Sci. 2007 Oct;32(10):450-6. doi: 10.1016/j.tibs.2007.09.001. Trends Biochem Sci. 2007. PMID: 17920279
PI3K comes of age.
Ward SG, Finan P, Welham MJ. Ward SG, et al. Nat Immunol. 2003 Jan;4(1):2. doi: 10.1038/ni0103-2. Nat Immunol. 2003. PMID: 12496966 No abstract available.
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