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157 results

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Page 1
Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain.
Hirsch-Reinshagen V, Zhou S, Burgess BL, Bernier L, McIsaac SA, Chan JY, Tansley GH, Cohn JS, Hayden MR, Wellington CL. Hirsch-Reinshagen V, et al. Among authors: wellington cl. J Biol Chem. 2004 Sep 24;279(39):41197-207. doi: 10.1074/jbc.M407962200. Epub 2004 Jul 21. J Biol Chem. 2004. PMID: 15269218 Free article.
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.
Hirsch-Reinshagen V, Maia LF, Burgess BL, Blain JF, Naus KE, McIsaac SA, Parkinson PF, Chan JY, Tansley GH, Hayden MR, Poirier J, Van Nostrand W, Wellington CL. Hirsch-Reinshagen V, et al. Among authors: wellington cl. J Biol Chem. 2005 Dec 30;280(52):43243-56. doi: 10.1074/jbc.M508781200. Epub 2005 Oct 5. J Biol Chem. 2005. PMID: 16207707 Free article.
Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma.
Burgess BL, McIsaac SA, Naus KE, Chan JY, Tansley GH, Yang J, Miao F, Ross CJ, van Eck M, Hayden MR, van Nostrand W, St George-Hyslop P, Westaway D, Wellington CL. Burgess BL, et al. Among authors: wellington cl. Neurobiol Dis. 2006 Oct;24(1):114-27. doi: 10.1016/j.nbd.2006.06.007. Epub 2006 Aug 8. Neurobiol Dis. 2006. PMID: 16899370
The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein.
Tansley GH, Burgess BL, Bryan MT, Su Y, Hirsch-Reinshagen V, Pearce J, Chan JY, Wilkinson A, Evans J, Naus KE, McIsaac S, Bromley K, Song W, Yang HC, Wang N, DeMattos RB, Wellington CL. Tansley GH, et al. Among authors: wellington cl. J Lipid Res. 2007 May;48(5):1022-34. doi: 10.1194/jlr.M600542-JLR200. Epub 2007 Feb 10. J Lipid Res. 2007. PMID: 17293612 Free article.
ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.
Burgess BL, Parkinson PF, Racke MM, Hirsch-Reinshagen V, Fan J, Wong C, Stukas S, Theroux L, Chan JY, Donkin J, Wilkinson A, Balik D, Christie B, Poirier J, Lütjohann D, Demattos RB, Wellington CL. Burgess BL, et al. Among authors: wellington cl. J Lipid Res. 2008 Jun;49(6):1254-67. doi: 10.1194/jlr.M700481-JLR200. Epub 2008 Feb 26. J Lipid Res. 2008. PMID: 18314463 Free article.
Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice.
Burgess B, Naus K, Chan J, Hirsch-Reinshagen V, Tansley G, Matzke L, Chan B, Wilkinson A, Fan J, Donkin J, Balik D, Tanaka T, Ou G, Dyer R, Innis S, McManus B, Lütjohann D, Wellington C. Burgess B, et al. Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1731-7. doi: 10.1161/ATVBAHA.108.168542. Epub 2008 Jul 3. Arterioscler Thromb Vasc Biol. 2008. PMID: 18599800
LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins.
Hirsch-Reinshagen V, Donkin J, Stukas S, Chan J, Wilkinson A, Fan J, Parks JS, Kuivenhoven JA, Lütjohann D, Pritchard H, Wellington CL. Hirsch-Reinshagen V, et al. Among authors: wellington cl. J Lipid Res. 2009 May;50(5):885-93. doi: 10.1194/jlr.M800584-JLR200. Epub 2008 Dec 8. J Lipid Res. 2009. PMID: 19065001 Free PMC article.
Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.
Karasinska JM, Rinninger F, Lütjohann D, Ruddle P, Franciosi S, Kruit JK, Singaraja RR, Hirsch-Reinshagen V, Fan J, Brunham LR, Bissada N, Ramakrishnan R, Wellington CL, Parks JS, Hayden MR. Karasinska JM, et al. Among authors: wellington cl. J Neurosci. 2009 Mar 18;29(11):3579-89. doi: 10.1523/JNEUROSCI.4741-08.2009. J Neurosci. 2009. PMID: 19295162 Free PMC article.
Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function.
Kruit JK, Wijesekara N, Westwell-Roper C, Vanmierlo T, de Haan W, Bhattacharjee A, Tang R, Wellington CL, LütJohann D, Johnson JD, Brunham LR, Verchere CB, Hayden MR. Kruit JK, et al. Among authors: wellington cl. Diabetes. 2012 Mar;61(3):659-64. doi: 10.2337/db11-1341. Epub 2012 Feb 7. Diabetes. 2012. PMID: 22315310 Free PMC article.
157 results