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P21-activated kinase 4--not just one of the PAK.
Dart AE, Wells CM. Dart AE, et al. Among authors: wells cm. Eur J Cell Biol. 2013 Apr-May;92(4-5):129-38. doi: 10.1016/j.ejcb.2013.03.002. Epub 2013 Apr 4. Eur J Cell Biol. 2013. PMID: 23642861 Review.
Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages.
Vanhaesebroeck B, Jones GE, Allen WE, Zicha D, Hooshmand-Rad R, Sawyer C, Wells C, Waterfield MD, Ridley AJ. Vanhaesebroeck B, et al. Nat Cell Biol. 1999 May;1(1):69-71. doi: 10.1038/9045. Nat Cell Biol. 1999. PMID: 10559867 No abstract available.
PAK4 is activated via PI3K in HGF-stimulated epithelial cells.
Wells CM, Abo A, Ridley AJ. Wells CM, et al. J Cell Sci. 2002 Oct 15;115(Pt 20):3947-56. doi: 10.1242/jcs.00080. J Cell Sci. 2002. PMID: 12244132
Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration.
Wells CM, Walmsley M, Ooi S, Tybulewicz V, Ridley AJ. Wells CM, et al. J Cell Sci. 2004 Mar 1;117(Pt 7):1259-68. doi: 10.1242/jcs.00997. J Cell Sci. 2004. PMID: 14996945
Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization.
Wells CM, Bhavsar PJ, Evans IR, Vigorito E, Turner M, Tybulewicz V, Ridley AJ. Wells CM, et al. Exp Cell Res. 2005 Nov 1;310(2):303-10. doi: 10.1016/j.yexcr.2005.07.015. Epub 2005 Aug 31. Exp Cell Res. 2005. PMID: 16137676
Rho family GTPases are activated during HGF-stimulated prostate cancer-cell scattering.
Wells CM, Ahmed T, Masters JR, Jones GE. Wells CM, et al. Cell Motil Cytoskeleton. 2005 Nov;62(3):180-94. doi: 10.1002/cm.20095. Cell Motil Cytoskeleton. 2005. PMID: 16211585
Rac1 and Rac2 regulate macrophage morphology but are not essential for migration.
Wheeler AP, Wells CM, Smith SD, Vega FM, Henderson RB, Tybulewicz VL, Ridley AJ. Wheeler AP, et al. Among authors: wells cm. J Cell Sci. 2006 Jul 1;119(Pt 13):2749-57. doi: 10.1242/jcs.03024. Epub 2006 Jun 13. J Cell Sci. 2006. PMID: 16772332
A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF.
Ahmed T, Shea K, Masters JR, Jones GE, Wells CM. Ahmed T, et al. Among authors: wells cm. Cell Signal. 2008 Jul;20(7):1320-8. doi: 10.1016/j.cellsig.2008.02.021. Epub 2008 Mar 12. Cell Signal. 2008. PMID: 18424072
The emerging importance of group II PAKs.
Wells CM, Jones GE. Wells CM, et al. Biochem J. 2010 Jan 15;425(3):465-73. doi: 10.1042/BJ20091173. Biochem J. 2010. PMID: 20070256 Review.
PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion.
Wells CM, Whale AD, Parsons M, Masters JR, Jones GE. Wells CM, et al. J Cell Sci. 2010 May 15;123(Pt 10):1663-73. doi: 10.1242/jcs.055707. Epub 2010 Apr 20. J Cell Sci. 2010. PMID: 20406887 Free PMC article.
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