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A common allosteric site and mechanism in caspases.
Scheer JM, Romanowski MJ, Wells JA. Scheer JM, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7595-600. doi: 10.1073/pnas.0602571103. Epub 2006 May 8. Proc Natl Acad Sci U S A. 2006. PMID: 16682620 Free PMC article.
Tags for labeling protein N-termini with subtiligase for proteomics.
Yoshihara HA, Mahrus S, Wells JA. Yoshihara HA, et al. Among authors: wells ja. Bioorg Med Chem Lett. 2008 Nov 15;18(22):6000-3. doi: 10.1016/j.bmcl.2008.08.044. Epub 2008 Aug 19. Bioorg Med Chem Lett. 2008. PMID: 18762420 Free PMC article.
Two-state selection of conformation-specific antibodies.
Gao J, Sidhu SS, Wells JA. Gao J, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3071-6. doi: 10.1073/pnas.0812952106. Epub 2009 Feb 10. Proc Natl Acad Sci U S A. 2009. PMID: 19208804 Free PMC article.
Small-molecule activators of a proenzyme.
Wolan DW, Zorn JA, Gray DC, Wells JA. Wolan DW, et al. Among authors: wells ja. Science. 2009 Nov 6;326(5954):853-8. doi: 10.1126/science.1177585. Science. 2009. PMID: 19892984 Free PMC article.
Prediction of protease substrates using sequence and structure features.
Barkan DT, Hostetter DR, Mahrus S, Pieper U, Wells JA, Craik CS, Sali A. Barkan DT, et al. Among authors: wells ja. Bioinformatics. 2010 Jul 15;26(14):1714-22. doi: 10.1093/bioinformatics/btq267. Epub 2010 May 26. Bioinformatics. 2010. PMID: 20505003 Free PMC article.
Identification of specific tethered inhibitors for caspase-5.
Gao J, Wells JA. Gao J, et al. Among authors: wells ja. Chem Biol Drug Des. 2012 Feb;79(2):209-15. doi: 10.1111/j.1747-0285.2011.01261.x. Epub 2011 Nov 28. Chem Biol Drug Des. 2012. PMID: 22014003 Free PMC article.
Global kinetic analysis of proteolysis via quantitative targeted proteomics.
Agard NJ, Mahrus S, Trinidad JC, Lynn A, Burlingame AL, Wells JA. Agard NJ, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1913-8. doi: 10.1073/pnas.1117158109. Epub 2012 Jan 23. Proc Natl Acad Sci U S A. 2012. PMID: 22308409 Free PMC article.
513 results