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Caspase substrates and cellular remodeling.
Crawford ED, Wells JA. Crawford ED, et al. Annu Rev Biochem. 2011;80:1055-87. doi: 10.1146/annurev-biochem-061809-121639. Annu Rev Biochem. 2011. PMID: 21456965 Review.
Mechanistic diversity of cytokine receptor signaling across cell membranes.
Stroud RM, Wells JA. Stroud RM, et al. Sci STKE. 2004 Apr 28;2004(231):re7. doi: 10.1126/stke.2312004re7. Sci STKE. 2004. PMID: 15126678 Review.
Tethering: fragment-based drug discovery.
Erlanson DA, Wells JA, Braisted AC. Erlanson DA, et al. Annu Rev Biophys Biomol Struct. 2004;33:199-223. doi: 10.1146/annurev.biophys.33.110502.140409. Annu Rev Biophys Biomol Struct. 2004. PMID: 15139811 Review.
Discovery of an allosteric site in the caspases.
Hardy JA, Lam J, Nguyen JT, O'Brien T, Wells JA. Hardy JA, et al. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12461-6. doi: 10.1073/pnas.0404781101. Epub 2004 Aug 16. Proc Natl Acad Sci U S A. 2004. PMID: 15314233 Free PMC article.
Searching for new allosteric sites in enzymes.
Hardy JA, Wells JA. Hardy JA, et al. Curr Opin Struct Biol. 2004 Dec;14(6):706-15. doi: 10.1016/j.sbi.2004.10.009. Curr Opin Struct Biol. 2004. PMID: 15582395 Review.
A common allosteric site and mechanism in caspases.
Scheer JM, Romanowski MJ, Wells JA. Scheer JM, et al. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7595-600. doi: 10.1073/pnas.0602571103. Epub 2006 May 8. Proc Natl Acad Sci U S A. 2006. PMID: 16682620 Free PMC article.
An allosteric circuit in caspase-1.
Datta D, Scheer JM, Romanowski MJ, Wells JA. Datta D, et al. J Mol Biol. 2008 Sep 19;381(5):1157-67. doi: 10.1016/j.jmb.2008.06.040. Epub 2008 Jun 20. J Mol Biol. 2008. PMID: 18590738 Free PMC article.
Two-state selection of conformation-specific antibodies.
Gao J, Sidhu SS, Wells JA. Gao J, et al. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3071-6. doi: 10.1073/pnas.0812952106. Epub 2009 Feb 10. Proc Natl Acad Sci U S A. 2009. PMID: 19208804 Free PMC article.
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