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424 results
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Caspases and their substrates.
Julien O, Wells JA. Julien O, et al. Among authors: wells ja. Cell Death Differ. 2017 Aug;24(8):1380-1389. doi: 10.1038/cdd.2017.44. Epub 2017 May 12. Cell Death Differ. 2017. PMID: 28498362 Free PMC article. Review.
Global cellular response to chemotherapy-induced apoptosis.
Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. Wiita AP, et al. Among authors: wells ja. Elife. 2013 Oct 29;2:e01236. doi: 10.7554/eLife.01236. Elife. 2013. PMID: 24171104 Free PMC article.
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. Ostrem JM, et al. Among authors: wells ja. Nature. 2013 Nov 28;503(7477):548-51. doi: 10.1038/nature12796. Epub 2013 Nov 20. Nature. 2013. PMID: 24256730 Free PMC article.
Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling.
Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA. Wiita AP, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7594-9. doi: 10.1073/pnas.1405987111. Epub 2014 May 12. Proc Natl Acad Sci U S A. 2014. PMID: 24821784 Free PMC article.
Turning on caspases with genetics and small molecules.
Morgan CW, Julien O, Unger EK, Shah NM, Wells JA. Morgan CW, et al. Among authors: wells ja. Methods Enzymol. 2014;544:179-213. doi: 10.1016/B978-0-12-417158-9.00008-X. Methods Enzymol. 2014. PMID: 24974291 Free PMC article. Review.
Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini.
Wiita AP, Seaman JE, Wells JA. Wiita AP, et al. Among authors: wells ja. Methods Enzymol. 2014;544:327-58. doi: 10.1016/B978-0-12-417158-9.00013-3. Methods Enzymol. 2014. PMID: 24974296 Free PMC article.
Unraveling the mechanism of cell death induced by chemical fibrils.
Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Julien O, et al. Among authors: wells ja. Nat Chem Biol. 2014 Nov;10(11):969-76. doi: 10.1038/nchembio.1639. Epub 2014 Sep 28. Nat Chem Biol. 2014. PMID: 25262416 Free PMC article.
Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.
Ordureau A, Sarraf SA, Duda DM, Heo JM, Jedrychowski MP, Sviderskiy VO, Olszewski JL, Koerber JT, Xie T, Beausoleil SA, Wells JA, Gygi SP, Schulman BA, Harper JW. Ordureau A, et al. Among authors: wells ja. Mol Cell. 2014 Nov 6;56(3):360-75. doi: 10.1016/j.molcel.2014.09.007. Epub 2014 Oct 2. Mol Cell. 2014. PMID: 25284222 Free PMC article.
A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.
Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. Rettenmaier TJ, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. doi: 10.1073/pnas.1415365112. Epub 2014 Dec 17. Proc Natl Acad Sci U S A. 2014. PMID: 25518860 Free PMC article.
Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling.
Morgan CW, Diaz JE, Zeitlin SG, Gray DC, Wells JA. Morgan CW, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8344-9. doi: 10.1073/pnas.1504141112. Epub 2015 Jun 23. Proc Natl Acad Sci U S A. 2015. PMID: 26106156 Free PMC article.
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