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Silibinin and its 2,3-dehydro-derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation.
Tilley C, Deep G, Agarwal C, Wempe MF, Biedermann D, Valentová K, Kren V, Agarwal R. Tilley C, et al. Among authors: Wempe MF. Mol Carcinog. 2016 Jan;55(1):3-14. doi: 10.1002/mc.22253. Epub 2014 Dec 9. Mol Carcinog. 2016. PMID: 25492239 Free PMC article.
Procyanidin B2 3,3″-di-O-gallate induces oxidative stress-mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK.
Kumar R, Deep G, Wempe MF, Surek J, Kumar A, Agarwal R, Agarwal C. Kumar R, et al. Among authors: Wempe MF. Mol Carcinog. 2018 Jan;57(1):57-69. doi: 10.1002/mc.22731. Epub 2017 Sep 22. Mol Carcinog. 2018. PMID: 28876465 Free PMC article.
Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma.
Cormerais Y, Pagnuzzi-Boncompagni M, Schrötter S, Giuliano S, Tambutté E, Endou H, Wempe MF, Pagès G, Pouysségur J, Picco V. Cormerais Y, et al. Among authors: Wempe MF. J Cell Mol Med. 2019 Apr;23(4):2711-2718. doi: 10.1111/jcmm.14176. Epub 2019 Feb 19. J Cell Mol Med. 2019. PMID: 30784173 Free PMC article.
The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5).
Cormerais Y, Massard PA, Vucetic M, Giuliano S, Tambutté E, Durivault J, Vial V, Endou H, Wempe MF, Parks SK, Pouyssegur J. Cormerais Y, et al. Among authors: Wempe MF. J Biol Chem. 2018 Feb 23;293(8):2877-2887. doi: 10.1074/jbc.RA117.001342. Epub 2018 Jan 11. J Biol Chem. 2018. PMID: 29326164 Free PMC article.
Synthesis of novel Ral inhibitors: An in vitro and in vivo study.
Yan C, Theodorescu D, Miller B, Kumar A, Kumar V, Ross D, Wempe MF. Yan C, et al. Among authors: Wempe MF. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5815-5818. doi: 10.1016/j.bmcl.2016.10.021. Epub 2016 Oct 12. Bioorg Med Chem Lett. 2016. PMID: 27825764 Free PMC article.
Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo.
Kavitha CV, Jain AK, Agarwal C, Pierce A, Keating A, Huber KM, Serkova NJ, Wempe MF, Agarwal R, Deep G. Kavitha CV, et al. Among authors: Wempe MF. Mol Carcinog. 2015 Nov;54(11):1417-29. doi: 10.1002/mc.22220. Epub 2014 Sep 22. Mol Carcinog. 2015. PMID: 25252179 Free PMC article.
Procyanidin B2 3,3(″)-di-O-gallate, a biologically active constituent of grape seed extract, induces apoptosis in human prostate cancer cells via targeting NF-κB, Stat3, and AP1 transcription factors.
Tyagi A, Raina K, Shrestha SP, Miller B, Thompson JA, Wempe MF, Agarwal R, Agarwal C. Tyagi A, et al. Among authors: Wempe MF. Nutr Cancer. 2014;66(4):736-46. doi: 10.1080/01635581.2013.783602. Epub 2013 Nov 5. Nutr Cancer. 2014. PMID: 24191894 Free PMC article.
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