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Year Number of Results
2009 1
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21 results

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Page 1
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, Hong S, Shi Y, Santana M, Kueth C, Macklin-Isquierdo S, Perry S, Duhaime S, Maios C, Chang J, Perez J, Couto A, Lai J, Li Y, Alworth SV, Hendricks E, Wang Y, Zlokovic BV, Dickman DK, Parker JA, Zarnescu DC, Gao FB, Ichida JK. Hung ST, et al. Among authors: chang wh. Cell. 2023 Feb 16;186(4):786-802.e28. doi: 10.1016/j.cell.2023.01.005. Epub 2023 Feb 7. Cell. 2023. PMID: 36754049 Free PMC article.
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.
Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK. Shi Y, et al. Among authors: chang wh. Nat Med. 2018 Mar;24(3):313-325. doi: 10.1038/nm.4490. Epub 2018 Feb 5. Nat Med. 2018. PMID: 29400714 Free PMC article.
Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors Is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer.
Drizyte-Miller K, Engstrom LD, Klomp JA, Stalnecker CA, Stamey AG, Taylor KE, Roach MK, Robb R, Waters LM, Calinisan A, Degan S, Chang WH, Helu XM, Nguyen D, Baldelli E, Pierobon M, Petricoin EF, Briere DM, Hallin J, Christensen JG, Bryant KL, Cox AD, Olson P, Der CJ. Drizyte-Miller K, et al. Among authors: chang wh. Cancer Res. 2025 Sep 15;85(18):3540-3557. doi: 10.1158/0008-5472.CAN-25-1507. Cancer Res. 2025. PMID: 40694535 Free PMC article.
CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer.
Long SA, Todd H, Goodhart G, Chang WH, Amparo AM, Bridgens R, Dilly J, Park SJ, Beal RM, Shehadeh SM, Satyadi MA, Trivedi VK, Ackermann SE, Mukherjee R, Goodwin CM, Edwards AC, Stalnecker CA, Greis KD, Aguirre AJ, Hobbs GA, Bryant KL, Ahmad SA, Cox AD, Der CJ, Waters AM. Long SA, et al. Among authors: chang wh. Cancer Res. 2026 Feb 16;86(4):1035-1053. doi: 10.1158/0008-5472.CAN-25-1835. Cancer Res. 2026. PMID: 41248420 Free PMC article.
SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS.
Linares GR, Li Y, Chang WH, Rubin-Sigler J, Mendonca S, Hong S, Eoh Y, Guo W, Huang YH, Chang J, Tu S, Dorjsuren N, Santana M, Hung ST, Yu J, Perez J, Chickering M, Cheng TY, Huang CC, Lee SJ, Deng HJ, Bach KT, Gray K, Subramanyam V, Rosenfeld J, Alworth SV, Goodarzi H, Ichida JK. Linares GR, et al. Among authors: chang wh. Cell Stem Cell. 2023 Feb 2;30(2):171-187.e14. doi: 10.1016/j.stem.2023.01.005. Cell Stem Cell. 2023. PMID: 36736291 Free PMC article.
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, Hong S, Shi Y, Santana M, Kueth C, Macklin-Isquierdo S, Perry S, Duhaime S, Maios C, Chang J, Perez J, Couto A, Lai J, Li Y, Alworth SV, Hendricks E, Wang Y, Zlokovic BV, Dickman DK, Parker JA, Zarnescu DC, Gao FB, Ichida JK. Hung ST, et al. Among authors: chang wh. Cell. 2026 Feb 5;189(3):987-992. doi: 10.1016/j.cell.2026.01.004. Epub 2026 Jan 24. Cell. 2026. PMID: 41581503 Free article. No abstract available.
Characterization and therapeutic suppression of KEAP1-NRF2-driven resistance to KRAS inhibitors in pancreatic and lung cancer.
Chang WH, Vaughan AJ, Stamey AG, Mancini M, Hayashi M, Yang R, Robb R, Andrussier D, Klomp JA, Waters AM, Schaefer A, Wolpin BM, Bryant KL, Cox AD, Simabuco FM, Wong KK, Aguirre AJ, Stalnecker CA, Papagiannakopoulos T, Der CJ. Chang WH, et al. bioRxiv [Preprint]. 2026 Apr 21:2026.04.18.719329. doi: 10.64898/2026.04.18.719329. bioRxiv. 2026. PMID: 42079131 Free PMC article. Preprint.
Dordaviprone/ONC201 Activation of the ClpP Mitochondrial Protease Inhibits the Growth of KRAS-Mutant Pancreatic Cancer and Overcomes RAS Inhibitor Resistance.
Drizyte-Miller K, Degan SE, Mouery RD, Amparo AM, Mouery BL, Chang WH, Yang R, Nicewarner Peña SR, Baldelli E, Klomp JA, Iwanowicz EJ, Graves LM, Petricoin EF, Cox AD, Stalnecker CA, Bryant KL, Der CJ. Drizyte-Miller K, et al. Among authors: chang wh. bioRxiv [Preprint]. 2025 Dec 3:2025.12.01.691471. doi: 10.64898/2025.12.01.691471. bioRxiv. 2025. PMID: 41573866 Free PMC article. Preprint.
Rad51 facilitates filament assembly of meiosis-specific Dmc1 recombinase.
Lan WH, Lin SY, Kao CY, Chang WH, Yeh HY, Chang HY, Chi P, Li HW. Lan WH, et al. Among authors: chang wh. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11257-11264. doi: 10.1073/pnas.1920368117. Epub 2020 May 13. Proc Natl Acad Sci U S A. 2020. PMID: 32404423 Free PMC article.
21 results