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2009 1
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21 results

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Page 1
Characterization and therapeutic suppression of KEAP1-NRF2-driven resistance to KRAS inhibitors in pancreatic and lung cancer.
Chang WH, Vaughan AJ, Stamey AG, Mancini M, Hayashi M, Yang R, Robb R, Andrussier D, Klomp JA, Waters AM, Schaefer A, Wolpin BM, Bryant KL, Cox AD, Simabuco FM, Wong KK, Aguirre AJ, Stalnecker CA, Papagiannakopoulos T, Der CJ. Chang WH, et al. bioRxiv [Preprint]. 2026 Apr 21:2026.04.18.719329. doi: 10.64898/2026.04.18.719329. bioRxiv. 2026. PMID: 42079131 Free PMC article. Preprint.
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, Hong S, Shi Y, Santana M, Kueth C, Macklin-Isquierdo S, Perry S, Duhaime S, Maios C, Chang J, Perez J, Couto A, Lai J, Li Y, Alworth SV, Hendricks E, Wang Y, Zlokovic BV, Dickman DK, Parker JA, Zarnescu DC, Gao FB, Ichida JK. Hung ST, et al. Among authors: chang wh. Cell. 2026 Feb 5;189(3):987-992. doi: 10.1016/j.cell.2026.01.004. Epub 2026 Jan 24. Cell. 2026. PMID: 41581503 Free article. No abstract available.
Dordaviprone/ONC201 Activation of the ClpP Mitochondrial Protease Inhibits the Growth of KRAS-Mutant Pancreatic Cancer and Overcomes RAS Inhibitor Resistance.
Drizyte-Miller K, Degan SE, Mouery RD, Amparo AM, Mouery BL, Chang WH, Yang R, Nicewarner Peña SR, Baldelli E, Klomp JA, Iwanowicz EJ, Graves LM, Petricoin EF, Cox AD, Stalnecker CA, Bryant KL, Der CJ. Drizyte-Miller K, et al. Among authors: chang wh. bioRxiv [Preprint]. 2025 Dec 3:2025.12.01.691471. doi: 10.64898/2025.12.01.691471. bioRxiv. 2025. PMID: 41573866 Free PMC article. Preprint.
CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer.
Long SA, Todd H, Goodhart G, Chang WH, Amparo AM, Bridgens R, Dilly J, Park SJ, Beal RM, Shehadeh SM, Satyadi MA, Trivedi VK, Ackermann SE, Mukherjee R, Goodwin CM, Edwards AC, Stalnecker CA, Greis KD, Aguirre AJ, Hobbs GA, Bryant KL, Ahmad SA, Cox AD, Der CJ, Waters AM. Long SA, et al. Among authors: chang wh. Cancer Res. 2026 Feb 16;86(4):1035-1053. doi: 10.1158/0008-5472.CAN-25-1835. Cancer Res. 2026. PMID: 41248420 Free PMC article.
Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors Is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer.
Drizyte-Miller K, Engstrom LD, Klomp JA, Stalnecker CA, Stamey AG, Taylor KE, Roach MK, Robb R, Waters LM, Calinisan A, Degan S, Chang WH, Helu XM, Nguyen D, Baldelli E, Pierobon M, Petricoin EF, Briere DM, Hallin J, Christensen JG, Bryant KL, Cox AD, Olson P, Der CJ. Drizyte-Miller K, et al. Among authors: chang wh. Cancer Res. 2025 Sep 15;85(18):3540-3557. doi: 10.1158/0008-5472.CAN-25-1507. Cancer Res. 2025. PMID: 40694535 Free PMC article.
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, Hong S, Shi Y, Santana M, Kueth C, Macklin-Isquierdo S, Perry S, Duhaime S, Maios C, Chang J, Perez J, Couto A, Lai J, Li Y, Alworth SV, Hendricks E, Wang Y, Zlokovic BV, Dickman DK, Parker JA, Zarnescu DC, Gao FB, Ichida JK. Hung ST, et al. Among authors: chang wh. Cell. 2023 Feb 16;186(4):786-802.e28. doi: 10.1016/j.cell.2023.01.005. Epub 2023 Feb 7. Cell. 2023. PMID: 36754049 Free PMC article.
SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS.
Linares GR, Li Y, Chang WH, Rubin-Sigler J, Mendonca S, Hong S, Eoh Y, Guo W, Huang YH, Chang J, Tu S, Dorjsuren N, Santana M, Hung ST, Yu J, Perez J, Chickering M, Cheng TY, Huang CC, Lee SJ, Deng HJ, Bach KT, Gray K, Subramanyam V, Rosenfeld J, Alworth SV, Goodarzi H, Ichida JK. Linares GR, et al. Among authors: chang wh. Cell Stem Cell. 2023 Feb 2;30(2):171-187.e14. doi: 10.1016/j.stem.2023.01.005. Cell Stem Cell. 2023. PMID: 36736291 Free PMC article.
21 results