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Promising therapeutic targets for antileishmanial drugs.
Werbovetz KA. Werbovetz KA. Expert Opin Ther Targets. 2002 Aug;6(4):407-22. doi: 10.1517/14728222.6.4.407. Expert Opin Ther Targets. 2002. PMID: 12223057 Review.
Cytotoxicity of acridine compounds for Leishmania promastigotes in vitro.
Werbovetz KA, Lehnert EK, Macdonald TL, Pearson RD. Werbovetz KA, et al. Antimicrob Agents Chemother. 1992 Feb;36(2):495-7. doi: 10.1128/aac.36.2.495. Antimicrob Agents Chemother. 1992. PMID: 1318684 Free PMC article.
Target-based drug discovery for malaria, leishmaniasis, and trypanosomiasis.
Werbovetz KA. Werbovetz KA. Curr Med Chem. 2000 Aug;7(8):835-60. doi: 10.2174/0929867003374615. Curr Med Chem. 2000. PMID: 10828290 Review.
Antileishmanial dinitroaniline sulfonamides with activity against parasite tubulin.
Bhattacharya G, Salem MM, Werbovetz KA. Bhattacharya G, et al. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2395-8. doi: 10.1016/s0960-894x(02)00465-1. Bioorg Med Chem Lett. 2002. PMID: 12161141
Tubulin as an antiprotozoal drug target.
Werbovetz KA. Werbovetz KA. Mini Rev Med Chem. 2002 Dec;2(6):519-29. doi: 10.2174/1389557023405648. Mini Rev Med Chem. 2002. PMID: 12370037 Review.
Selective antimicrotubule activity of N1-phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB-II-5) against kinetoplastid parasites.
Werbovetz KA, Sackett DL, Delfín D, Bhattacharya G, Salem M, Obrzut T, Rattendi D, Bacchi C. Werbovetz KA, et al. Mol Pharmacol. 2003 Dec;64(6):1325-33. doi: 10.1124/mol.64.6.1325. Mol Pharmacol. 2003. PMID: 14645662
Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
Bhattacharya G, Herman J, Delfín D, Salem MM, Barszcz T, Mollet M, Riccio G, Brun R, Werbovetz KA. Bhattacharya G, et al. J Med Chem. 2004 Mar 25;47(7):1823-32. doi: 10.1021/jm0304461. J Med Chem. 2004. PMID: 15027874
Antikinetoplastid activity of 3-aryl-5-thiocyanatomethyl-1,2,4-oxadiazoles.
Cottrell DM, Capers J, Salem MM, DeLuca-Fradley K, Croft SL, Werbovetz KA. Cottrell DM, et al. Bioorg Med Chem. 2004 Jun 1;12(11):2815-24. doi: 10.1016/j.bmc.2004.03.054. Bioorg Med Chem. 2004. PMID: 15142541
Antiprotozoal compounds from Psorothamnus polydenius.
Salem MM, Werbovetz KA. Salem MM, et al. J Nat Prod. 2005 Jan;68(1):108-11. doi: 10.1021/np049682k. J Nat Prod. 2005. PMID: 15679330
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
Li PK, Xiao Z, Hu Z, Pandit B, Sun Y, Sackett DL, Werbovetz K, Lewis A, Johnsamuel J. Li PK, et al. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5382-5. doi: 10.1016/j.bmcl.2005.09.001. Epub 2005 Oct 6. Bioorg Med Chem Lett. 2005. PMID: 16213720
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