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The T-cell receptor signalosome: a dynamic structure with expanding complexity.
Werlen G, Palmer E. Werlen G, et al. Curr Opin Immunol. 2002 Jun;14(3):299-305. doi: 10.1016/s0952-7915(02)00339-4. Curr Opin Immunol. 2002. PMID: 11973126 Review.
Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development.
Chou PC, Oh WJ, Wu CC, Moloughney J, Rüegg MA, Hall MN, Jacinto E, Werlen G. Chou PC, et al. Among authors: werlen g. J Immunol. 2014 Aug 1;193(3):1162-70. doi: 10.4049/jimmunol.1303162. Epub 2014 Jun 30. J Immunol. 2014. PMID: 24981454 Free PMC article.
A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction.
Clarke RL, Thiemann S, Refaeli Y, Werlen G, Potter TA. Clarke RL, et al. Among authors: werlen g. Eur J Immunol. 2009 Jun;39(6):1619-31. doi: 10.1002/eji.200839062. Eur J Immunol. 2009. PMID: 19449311 Free PMC article.
Signaling life and death in the thymus: timing is everything.
Werlen G, Hausmann B, Naeher D, Palmer E. Werlen G, et al. Science. 2003 Mar 21;299(5614):1859-63. doi: 10.1126/science.1067833. Science. 2003. PMID: 12649474 Review.
A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity.
Werlen G, Hausmann B, Palmer E. Werlen G, et al. Nature. 2000 Jul 27;406(6794):422-6. doi: 10.1038/35019094. Nature. 2000. PMID: 10935640
The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model.
Rosette C, Werlen G, Daniels MA, Holman PO, Alam SM, Travers PJ, Gascoigne NR, Palmer E, Jameson SC. Rosette C, et al. Among authors: werlen g. Immunity. 2001 Jul;15(1):59-70. doi: 10.1016/s1074-7613(01)00173-x. Immunity. 2001. PMID: 11485738
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling.
Daniels MA, Teixeiro E, Gill J, Hausmann B, Roubaty D, Holmberg K, Werlen G, Holländer GA, Gascoigne NR, Palmer E. Daniels MA, et al. Among authors: werlen g. Nature. 2006 Dec 7;444(7120):724-9. doi: 10.1038/nature05269. Epub 2006 Nov 1. Nature. 2006. PMID: 17086201
mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1.
Moloughney JG, Kim PK, Vega-Cotto NM, Wu CC, Zhang S, Adlam M, Lynch T, Chou PC, Rabinowitz JD, Werlen G, Jacinto E. Moloughney JG, et al. Among authors: werlen g. Mol Cell. 2016 Sep 1;63(5):811-26. doi: 10.1016/j.molcel.2016.07.015. Epub 2016 Aug 25. Mol Cell. 2016. PMID: 27570073 Free PMC article.
mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation.
Moloughney JG, Vega-Cotto NM, Liu S, Patel C, Kim PK, Wu CC, Albaciete D, Magaway C, Chang A, Rajput S, Su X, Werlen G, Jacinto E. Moloughney JG, et al. Among authors: werlen g. J Biol Chem. 2018 Oct 19;293(42):16464-16478. doi: 10.1074/jbc.RA118.003991. Epub 2018 Sep 10. J Biol Chem. 2018. PMID: 30201609 Free PMC article.
Fascin1 promotes cell migration of mature dendritic cells.
Yamakita Y, Matsumura F, Lipscomb MW, Chou PC, Werlen G, Burkhardt JK, Yamashiro S. Yamakita Y, et al. Among authors: werlen g. J Immunol. 2011 Mar 1;186(5):2850-9. doi: 10.4049/jimmunol.1001667. Epub 2011 Jan 24. J Immunol. 2011. PMID: 21263068 Free PMC article.
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