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Natural regulatory T cells inhibit production of cytotoxic molecules in CD8⁺ T cells during low-level Friend retrovirus infection.
Zelinskyy G, Werner T, Dittmer U. Zelinskyy G, et al. Among authors: Werner T. Retrovirology. 2013 Oct 24;10:109. doi: 10.1186/1742-4690-10-109. Retrovirology. 2013. PMID: 24156479 Free PMC article.
In the current study, we elucidate the role of CD4⁺ regulatory T cells (Tregs) in suppressing the exocytosis pathway during an asymptomatic low-level infection. ...The expanded Tregs suppressed the proliferation of virus-specific CD8⁺ T cells and the production of c …
In the current study, we elucidate the role of CD4⁺ regulatory T cells (Tregs) in suppressing the exocytosis pathway during an asympt …
The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8(+) T Cells During an Acute Retroviral Infection.
David P, Megger DA, Kaiser T, Werner T, Liu J, Chen L, Sitek B, Dittmer U, Zelinskyy G. David P, et al. Among authors: Werner T. Front Immunol. 2019 Feb 5;10:54. doi: 10.3389/fimmu.2019.00054. eCollection 2019. Front Immunol. 2019. PMID: 30804928 Free PMC article.
Cytotoxic CD8(+) T lymphocytes (CTL) efficiently control acute virus infections but can become exhausted when a chronic infection develops. ...Furthermore, we performed a detailed analysis of the production of different granzymes in virus-specific CD8(+) T cells and …
Cytotoxic CD8(+) T lymphocytes (CTL) efficiently control acute virus infections but can become exhausted when a chronic infection dev …
Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8(+) T cell responses during acute Friend retrovirus infection.
Drabczyk-Pluta M, Werner T, Hoffmann D, Leng Q, Chen L, Dittmer U, Zelinskyy G. Drabczyk-Pluta M, et al. Among authors: Werner T. Retrovirology. 2017 Aug 23;14(1):42. doi: 10.1186/s12977-017-0364-3. Retrovirology. 2017. PMID: 28835242 Free PMC article.
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) can suppress T cell responses in several different diseases. Previously these suppressive cells were observed to expand in HIV patients and in a mouse retrovirus model, yet their suppressive effect on virus-specific CD8( …
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) can suppress T cell responses in several different diseases. Previously these su …
PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing.
Akhmetzyanova I, Drabczyk M, Neff CP, Gibbert K, Dietze KK, Werner T, Liu J, Chen L, Lang KS, Palmer BE, Dittmer U, Zelinskyy G. Akhmetzyanova I, et al. Among authors: Werner T. PLoS Pathog. 2015 Oct 20;11(10):e1005224. doi: 10.1371/journal.ppat.1005224. eCollection 2015 Oct. PLoS Pathog. 2015. PMID: 26484769 Free PMC article.
Cytotoxic CD8+ T Lymphocytes (CTL) efficiently control acute virus infections but can become exhausted when a chronic infection develops. Signaling of the inhibitory receptor PD-1 is an important mechanism for the development of virus-specific CD8+ T cell dysfunctio …
Cytotoxic CD8+ T Lymphocytes (CTL) efficiently control acute virus infections but can become exhausted when a chronic infection devel …
The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response.
Zelinskyy G, Dietze KK, Hüsecken YP, Schimmer S, Nair S, Werner T, Gibbert K, Kershaw O, Gruber AD, Sparwasser T, Dittmer U. Zelinskyy G, et al. Among authors: Werner T. Blood. 2009 Oct 8;114(15):3199-207. doi: 10.1182/blood-2009-03-208736. Epub 2009 Aug 11. Blood. 2009. PMID: 19671923
Cytotoxic CD8(+) T cells control acute viremia in many viral infections. However, most viruses that establish chronic infections evade destruction by CD8(+) T cells, and regulatory T cells (Treg) are thought to be involved in this immune evasion. ...Experimen …
Cytotoxic CD8(+) T cells control acute viremia in many viral infections. However, most viruses that establish chronic infections evad …
The level of friend retrovirus replication determines the cytolytic pathway of CD8+ T-cell-mediated pathogen control.
Zelinskyy G, Balkow S, Schimmer S, Werner T, Simon MM, Dittmer U. Zelinskyy G, et al. Among authors: Werner T. J Virol. 2007 Nov;81(21):11881-90. doi: 10.1128/JVI.01554-07. Epub 2007 Aug 29. J Virol. 2007. PMID: 17728236 Free PMC article.
Both the low- and high-level F-MuLV infections generated CD8+ effector T cells that were essential for the control of viral replication. However, the low-level infection induced CD8+ T cells expressing solely FasL but not the cytotoxic molecules granzymes A and B, w …
Both the low- and high-level F-MuLV infections generated CD8+ effector T cells that were essential for the control of viral replicati …
Co-immunization of mice with a retroviral DNA vaccine and GITRL-encoding plasmid augments vaccine-induced protection against retrovirus infection.
Dittmer U, Werner T, Kraft AR. Dittmer U, et al. Among authors: Werner T. Viral Immunol. 2008 Dec;21(4):459-67. doi: 10.1089/vim.2008.0046. Viral Immunol. 2008. PMID: 19115935
One strategy to enhance the efficiency of DNA vaccines is to augment effector T-cell priming against viral components by manipulating regulatory T-cell functions (Treg). ...
One strategy to enhance the efficiency of DNA vaccines is to augment effector T-cell priming against viral components by manipulating …
Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis.
Werner T, Wagner SJ, Martínez I, Walter J, Chang JS, Clavel T, Kisling S, Schuemann K, Haller D. Werner T, et al. Gut. 2011 Mar;60(3):325-33. doi: 10.1136/gut.2010.216929. Epub 2010 Nov 12. Gut. 2011. PMID: 21076126
Phenotype or reactivity of major effector intraepithelial CD8αβ(+) T cells were not altered in the absence of luminal iron. Interestingly, ER stress mechanisms sensitised the small intestinal epithelial cell (IEC) line Mode-K to cytotoxic function of effector T cell …
Phenotype or reactivity of major effector intraepithelial CD8αβ(+) T cells were not altered in the absence of luminal iron. Interesti …
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