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Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.
Fritsch M, Günther SD, Schwarzer R, Albert MC, Schorn F, Werthenbach JP, Schiffmann LM, Stair N, Stocks H, Seeger JM, Lamkanfi M, Krönke M, Pasparakis M, Kashkar H. Fritsch M, et al. Among authors: werthenbach jp. Nature. 2019 Nov;575(7784):683-687. doi: 10.1038/s41586-019-1770-6. Epub 2019 Nov 20. Nature. 2019. PMID: 31748744
Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth.
Schiffmann LM, Werthenbach JP, Heintges-Kleinhofer F, Seeger JM, Fritsch M, Günther SD, Willenborg S, Brodesser S, Lucas C, Jüngst C, Albert MC, Schorn F, Witt A, Moraes CT, Bruns CJ, Pasparakis M, Krönke M, Eming SA, Coutelle O, Kashkar H. Schiffmann LM, et al. Among authors: werthenbach jp. Nat Commun. 2020 Jul 21;11(1):3653. doi: 10.1038/s41467-020-17472-2. Nat Commun. 2020. PMID: 32694534 Free PMC article.
XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.
Daoud M, Broxtermann PN, Schorn F, Werthenbach JP, Seeger JM, Schiffmann LM, Brinkmann K, Vucic D, Tüting T, Mauch C, Kulms D, Zigrino P, Kashkar H. Daoud M, et al. Among authors: werthenbach jp. EMBO Rep. 2022 Jun 7;23(6):e53608. doi: 10.15252/embr.202153608. Epub 2022 Apr 19. EMBO Rep. 2022. PMID: 35437868 Free PMC article.
Elevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma.
Schiffmann LM, Göbel H, Löser H, Schorn F, Werthenbach JP, Fuchs HF, Plum PS, Bludau M, Zander T, Schröder W, Bruns CJ, Kashkar H, Quaas A, Gebauer F. Schiffmann LM, et al. Among authors: werthenbach jp. BMC Cancer. 2019 May 31;19(1):531. doi: 10.1186/s12885-019-5722-1. BMC Cancer. 2019. PMID: 31151416 Free PMC article.