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MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.
Wesche H, Henzel WJ, Shillinglaw W, Li S, Cao Z. Wesche H, et al. Immunity. 1997 Dec;7(6):837-47. doi: 10.1016/s1074-7613(00)80402-1. Immunity. 1997. PMID: 9430229
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.
Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, Mirtsos C, Takada H, Wakeham A, Itie A, Li S, Penninger JM, Wesche H, Ohashi PS, Mak TW, Yeh WC. Suzuki N, et al. Among authors: wesche h. Nature. 2002 Apr 18;416(6882):750-6. doi: 10.1038/nature736. Epub 2002 Mar 31. Nature. 2002. PMID: 11923871
Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.
Kollewe C, Mackensen AC, Neumann D, Knop J, Cao P, Li S, Wesche H, Martin MU. Kollewe C, et al. Among authors: wesche h. J Biol Chem. 2004 Feb 13;279(7):5227-36. doi: 10.1074/jbc.M309251200. Epub 2003 Nov 18. J Biol Chem. 2004. PMID: 14625308
Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.
Powers JP, Li S, Jaen JC, Liu J, Walker NP, Wang Z, Wesche H. Powers JP, et al. Among authors: wesche h. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5. doi: 10.1016/j.bmcl.2006.03.020. Epub 2006 Mar 24. Bioorg Med Chem Lett. 2006. PMID: 16563752
IRAK-4 inhibitors for inflammation.
Wang Z, Wesche H, Stevens T, Walker N, Yeh WC. Wang Z, et al. Among authors: wesche h. Curr Top Med Chem. 2009;9(8):724-37. doi: 10.2174/156802609789044407. Curr Top Med Chem. 2009. PMID: 19689377 Free PMC article. Review.
Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper.
Wang Z, Liu J, Sudom A, Ayres M, Li S, Wesche H, Powers JP, Walker NP. Wang Z, et al. Among authors: wesche h. Structure. 2006 Dec;14(12):1835-44. doi: 10.1016/j.str.2006.11.001. Structure. 2006. PMID: 17161373
Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1.
van der Horst EH, Degenhardt YY, Strelow A, Slavin A, Chinn L, Orf J, Rong M, Li S, See LH, Nguyen KQ, Hoey T, Wesche H, Powers S. van der Horst EH, et al. Among authors: wesche h. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15901-6. doi: 10.1073/pnas.0508014102. Epub 2005 Oct 24. Proc Natl Acad Sci U S A. 2005. PMID: 16247015 Free PMC article.
IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.
Li S, Strelow A, Fontana EJ, Wesche H. Li S, et al. Among authors: wesche h. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5567-72. doi: 10.1073/pnas.082100399. Proc Natl Acad Sci U S A. 2002. PMID: 11960013 Free PMC article.
Characterization of Pellino2, a substrate of IRAK1 and IRAK4.
Strelow A, Kollewe C, Wesche H. Strelow A, et al. Among authors: wesche h. FEBS Lett. 2003 Jul 17;547(1-3):157-61. doi: 10.1016/s0014-5793(03)00697-5. FEBS Lett. 2003. PMID: 12860405
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