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M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase.
Glantschnig H, Fisher JE, Wesolowski G, Rodan GA, Reszka AA. Glantschnig H, et al. Among authors: wesolowski g. Cell Death Differ. 2003 Oct;10(10):1165-77. doi: 10.1038/sj.cdd.4401285. Cell Death Differ. 2003. PMID: 14502240
Soluble alpha v beta 3-integrin ligands raise [Ca2+]i in rat osteoclasts and mouse-derived osteoclast-like cells.
Zimolo Z, Wesolowski G, Tanaka H, Hyman JL, Hoyer JR, Rodan GA. Zimolo Z, et al. Among authors: wesolowski g. Am J Physiol. 1994 Feb;266(2 Pt 1):C376-81. doi: 10.1152/ajpcell.1994.266.2.C376. Am J Physiol. 1994. PMID: 8141251
Isolation and characterization of highly enriched, prefusion mouse osteoclastic cells.
Wesolowski G, Duong LT, Lakkakorpi PT, Nagy RM, Tezuka K, Tanaka H, Rodan GA, Rodan SB. Wesolowski G, et al. Exp Cell Res. 1995 Aug;219(2):679-86. doi: 10.1006/excr.1995.1279. Exp Cell Res. 1995. PMID: 7641819
Acid extrusion is induced by osteoclast attachment to bone. Inhibition by alendronate and calcitonin.
Zimolo Z, Wesolowski G, Rodan GA. Zimolo Z, et al. Among authors: wesolowski g. J Clin Invest. 1995 Nov;96(5):2277-83. doi: 10.1172/JCI118283. J Clin Invest. 1995. PMID: 7593614 Free PMC article.
Effects of acidic and basic fibroblast growth factors on osteoblastic cells.
Rodan SB, Wesolowski G, Thomas KA, Yoon K, Rodan GA. Rodan SB, et al. Among authors: wesolowski g. Connect Tissue Res. 1989;20(1-4):283-8. doi: 10.3109/03008208909023898. Connect Tissue Res. 1989. PMID: 2612159
Leukemia inhibitory factor binds with high affinity to preosteoblastic RCT-1 cells and potentiates the retinoic acid induction of alkaline phosphatase.
Rodan SB, Wesolowski G, Hilton DJ, Nicola NA, Rodan GA. Rodan SB, et al. Among authors: wesolowski g. Endocrinology. 1990 Oct;127(4):1602-8. doi: 10.1210/endo-127-4-1602. Endocrinology. 1990. PMID: 2119291
IL-1 binds to high affinity receptors on human osteosarcoma cells and potentiates prostaglandin E2 stimulation of cAMP production.
Rodan SB, Wesolowski G, Chin J, Limjuco GA, Schmidt JA, Rodan GA. Rodan SB, et al. Among authors: wesolowski g. J Immunol. 1990 Aug 15;145(4):1231-7. J Immunol. 1990. PMID: 2166111
Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist.
Duggan ME, Duong LT, Fisher JE, Hamill TG, Hoffman WF, Huff JR, Ihle NC, Leu CT, Nagy RM, Perkins JJ, Rodan SB, Wesolowski G, Whitman DB, Zartman AE, Rodan GA, Hartman GD. Duggan ME, et al. Among authors: wesolowski g. J Med Chem. 2000 Oct 5;43(20):3736-45. doi: 10.1021/jm000133v. J Med Chem. 2000. PMID: 11020288
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
Fisher JE, Rogers MJ, Halasy JM, Luckman SP, Hughes DE, Masarachia PJ, Wesolowski G, Russell RG, Rodan GA, Reszka AA. Fisher JE, et al. Among authors: wesolowski g. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8. doi: 10.1073/pnas.96.1.133. Proc Natl Acad Sci U S A. 1999. PMID: 9874784 Free PMC article.
Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate.
Schmidt A, Rutledge SJ, Endo N, Opas EE, Tanaka H, Wesolowski G, Leu CT, Huang Z, Ramachandaran C, Rodan SB, Rodan GA. Schmidt A, et al. Among authors: wesolowski g. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3068-73. doi: 10.1073/pnas.93.7.3068. Proc Natl Acad Sci U S A. 1996. PMID: 8610169 Free PMC article.
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