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Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet.
Wesson DE, Simoni J. Wesson DE, et al. Kidney Int. 2010 Dec;78(11):1128-35. doi: 10.1038/ki.2010.348. Epub 2010 Sep 22. Kidney Int. 2010. PMID: 20861823
Glomerular filtration effects of acute volume expansion: importance of chloride.
Wesson DE. Wesson DE. Kidney Int. 1987 Aug;32(2):238-45. doi: 10.1038/ki.1987.198. Kidney Int. 1987. PMID: 3656936
Endothelin-1 increases rat distal tubule acidification in vivo.
Wesson DE, Dolson GM. Wesson DE, et al. Am J Physiol. 1997 Oct;273(4):F586-94. doi: 10.1152/ajprenal.1997.273.4.F586. Am J Physiol. 1997. PMID: 9362336
Na/H exchange and H-K ATPase increase distal tubule acidification in chronic alkalosis.
Wesson DE. Wesson DE. Kidney Int. 1998 Apr;53(4):945-51. doi: 10.1111/j.1523-1755.1998.00838.x. Kidney Int. 1998. PMID: 9551402
Cigarette smoking is associated with augmented progression of renal insufficiency in severe essential hypertension.
Regalado M, Yang S, Wesson DE. Regalado M, et al. Among authors: wesson de. Am J Kidney Dis. 2000 Apr;35(4):687-94. doi: 10.1016/s0272-6386(00)70017-5. Am J Kidney Dis. 2000. PMID: 10739791
The initiation and progression of sickle cell nephropathy.
Wesson DE. Wesson DE. Kidney Int. 2002 Jun;61(6):2277-86. doi: 10.1046/j.1523-1755.2002.00363.x. Kidney Int. 2002. PMID: 12028473 No abstract available.
Increased endothelin activity mediates augmented distal nephron acidification induced by dietary protein.
Khanna A, Simoni J, Hacker C, Duran MJ, Wesson DE. Khanna A, et al. Among authors: wesson de. J Am Soc Nephrol. 2004 Sep;15(9):2266-75. doi: 10.1097/01.ASN.0000138233.78329.4E. J Am Soc Nephrol. 2004. PMID: 15339976
Endothelin-induced increased aldosterone activity mediates augmented distal nephron acidification as a result of dietary protein.
Khanna A, Simoni J, Wesson DE. Khanna A, et al. Among authors: wesson de. J Am Soc Nephrol. 2005 Jul;16(7):1929-35. doi: 10.1681/ASN.2004121054. Epub 2005 May 4. J Am Soc Nephrol. 2005. PMID: 15872074
Cigarette smoking enhances increased urine albumin excretion as a risk factor for glomerular filtration rate decline in primary hypertension.
Warmoth L, Regalado MM, Simoni J, Harrist RB, Wesson DE. Warmoth L, et al. Among authors: wesson de. Am J Med Sci. 2005 Sep;330(3):111-9. doi: 10.1097/00000441-200509000-00003. Am J Med Sci. 2005. PMID: 16174994
Increased endothelin activity mediates augmented distal nephron acidification induced by dietary protein.
Khanna A, Simoni J, Hacker C, Duran MJ, Wesson DE. Khanna A, et al. Among authors: wesson de. Trans Am Clin Climatol Assoc. 2005;116:239-56; discussion 257-8. Trans Am Clin Climatol Assoc. 2005. PMID: 16555618 Free PMC article.
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