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Mosaic sarbecovirus vaccination elicits cross-reactive responses in pre-immunized animals.
Cohen AA, Keeffe JR, Schiepers A, Dross SE, Greaney AJ, Rorick AV, Gao H, Gnanapragasam PNP, Fan C, West AP Jr, Ramsingh AI, Erasmus JH, Pata JD, Muramatsu H, Pardi N, Lin PJC, Baxter S, Cruz R, Quintanar-Audelo M, Robb E, Serrano-Amatriain C, Magneschi L, Fotheringham IG, Fuller DH, Victora GD, Bjorkman PJ. Cohen AA, et al. Among authors: west ap jr. bioRxiv [Preprint]. 2024 Feb 9:2024.02.08.576722. doi: 10.1101/2024.02.08.576722. bioRxiv. 2024. PMID: 38370696 Free PMC article. Preprint.
Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses.
Shrock EL, Timms RT, Kula T, Mena EL, West AP Jr, Guo R, Lee IH, Cohen AA, McKay LGA, Bi C, Leng Y, Fujimura E, Horns F, Li M, Wesemann DR, Griffiths A, Gewurz BE, Bjorkman PJ, Elledge SJ. Shrock EL, et al. Among authors: west ap jr. Science. 2023 Apr 7;380(6640):eadc9498. doi: 10.1126/science.adc9498. Epub 2023 Apr 7. Science. 2023. PMID: 37023193 Free PMC article.
CD4 binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wild-type animals.
Gristick HB, Hartweger H, Loewe M, van Schooten J, Ramos V, Oliveira TY, Nishimura Y, Koranda NS, Wall A, Yao KH, Poston D, Gazumyan A, Wiatr M, Horning M, Keeffe JR, Hoffmann MAG, Yang Z, Abernathy ME, Dam KA, Gao H, Gnanapragasam PNP, Kakutani LM, Pavlovitch-Bedzyk AJ, Seaman MS, Howarth M, McGuire AT, Stamatatos L, Martin MA, West AP Jr, Nussenzweig MC, Bjorkman PJ. Gristick HB, et al. Among authors: west ap jr. Sci Immunol. 2023 Feb 17;8(80):eade6364. doi: 10.1126/sciimmunol.ade6364. Epub 2023 Feb 10. Sci Immunol. 2023. PMID: 36763635 Free PMC article.
HLA-A∗02-gated safety switch for cancer therapy has exquisite specificity for its allelic target antigen.
Mock JY, Winters A, Riley TP, Bruno R, Naradikian MS, Sharma S, Jette CA, Elshimali R, Gahrs C, Toledo-Warshaviak D, West AP Jr, Kamb A, Hamburger AE. Mock JY, et al. Among authors: west ap jr. Mol Ther Oncolytics. 2022 Oct 4;27:157-166. doi: 10.1016/j.omto.2022.09.010. eCollection 2022 Dec 15. Mol Ther Oncolytics. 2022. PMID: 36381658 Free PMC article.
A naturally arising broad and potent CD4-binding site antibody with low somatic mutation.
Barnes CO, Schoofs T, Gnanapragasam PNP, Golijanin J, Huey-Tubman KE, Gruell H, Schommers P, Suh-Toma N, Lee YE, Cetrulo Lorenzi JC, Piechocka-Trocha A, Scheid JF, West AP Jr, Walker BD, Seaman MS, Klein F, Nussenzweig MC, Bjorkman PJ. Barnes CO, et al. Among authors: west ap jr. Sci Adv. 2022 Aug 12;8(32):eabp8155. doi: 10.1126/sciadv.abp8155. Epub 2022 Aug 12. Sci Adv. 2022. PMID: 35960796 Free PMC article.
Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models.
Cohen AA, van Doremalen N, Greaney AJ, Andersen H, Sharma A, Starr TN, Keeffe JR, Fan C, Schulz JE, Gnanapragasam PNP, Kakutani LM, West AP Jr, Saturday G, Lee YE, Gao H, Jette CA, Lewis MG, Tan TK, Townsend AR, Bloom JD, Munster VJ, Bjorkman PJ. Cohen AA, et al. Among authors: west ap jr. Science. 2022 Aug 5;377(6606):eabq0839. doi: 10.1126/science.abq0839. Epub 2022 Aug 5. Science. 2022. PMID: 35857620 Free PMC article.
Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models.
Cohen AA, van Doremalen N, Greaney AJ, Andersen H, Sharma A, Starr TN, Keeffe JR, Fan C, Schulz JE, Gnanapragasam PNP, Kakutani LM, West AP Jr, Saturday G, Lee YE, Gao H, Jette CA, Lewis MG, Tan TK, Townsend AR, Bloom JD, Munster VJ, Bjorkman PJ. Cohen AA, et al. Among authors: west ap jr. bioRxiv [Preprint]. 2022 Mar 28:2022.03.25.485875. doi: 10.1101/2022.03.25.485875. bioRxiv. 2022. PMID: 35378752 Free PMC article. Updated. Preprint.
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies.
Jette CA, Cohen AA, Gnanapragasam PNP, Muecksch F, Lee YE, Huey-Tubman KE, Schmidt F, Hatziioannou T, Bieniasz PD, Nussenzweig MC, West AP Jr, Keeffe JR, Bjorkman PJ, Barnes CO. Jette CA, et al. Among authors: west ap jr. Cell Rep. 2021 Dec 21;37(12):110188. doi: 10.1016/j.celrep.2021.110188. Cell Rep. 2021. PMID: 34936878 Free PMC article. No abstract available.
83 results