West NP - Search Results

1

First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.

Eng WS, Hocková D, Špaček P, Janeba Z, West NP, Woods K, Naesens LM, Keough DT, Guddat LW. Eng WS, et al. Among authors: west np. J Med Chem. 2015 Jun 11;58(11):4822-38. doi: 10.1021/acs.jmedchem.5b00611. Epub 2015 May 13. J Med Chem. 2015. PMID: 25915781

2

Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.

Keough DT, Hocková D, Rejman D, Spaček P, Vrbková S, Krečmerová M, Eng WS, Jans H, West NP, Naesens LM, de Jersey J, Guddat LW. Keough DT, et al. Among authors: west np. J Med Chem. 2013 Sep 12;56(17):6967-84. doi: 10.1021/jm400779n. Epub 2013 Aug 27. J Med Chem. 2013. PMID: 23927482

3

Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase.

Lonhienne T, Nouwens A, Williams CM, Fraser JA, Lee YT, West NP, Guddat LW. Lonhienne T, et al. Among authors: west np. Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4247-51. doi: 10.1002/anie.201511985. Epub 2016 Feb 29. Angew Chem Int Ed Engl. 2016. PMID: 26924714

4

Isothermal Point Mutation Detection: Toward a First-Pass Screening Strategy for Multidrug-Resistant Tuberculosis.

Ng BYC, Wee EJH, Woods K, Anderson W, Antaw F, Tsang HZH, West NP, Trau M. Ng BYC, et al. Among authors: west np. Anal Chem. 2017 Sep 5;89(17):9017-9022. doi: 10.1021/acs.analchem.7b01685. Epub 2017 Aug 15. Anal Chem. 2017. PMID: 28766343

5

Homologous alignment cloning: a rapid, flexible and highly efficient general molecular cloning method.

Tan L, Strong EJ, Woods K, West NP. Tan L, et al. Among authors: west np. PeerJ. 2018 Jun 29;6:e5146. doi: 10.7717/peerj.5146. eCollection 2018. PeerJ. 2018. PMID: 30038856 Free PMC article.

6

Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase.

Eng WS, Rejman D, Pohl R, West NP, Woods K, Naesens LMJ, Keough DT, Guddat LW. Eng WS, et al. Among authors: west np. Eur J Med Chem. 2018 Nov 5;159:10-22. doi: 10.1016/j.ejmech.2018.09.039. Epub 2018 Sep 19. Eur J Med Chem. 2018. PMID: 30265958

7

Design, Synthesis, and Biological Evaluation of 2-Nitroimidazopyrazin-one/-es with Antitubercular and Antiparasitic Activity.

Jarrad AM, Ang CW, Debnath A, Hahn HJ, Woods K, Tan L, Sykes ML, Jones AJ, Pelingon R, Butler MS, Avery VM, West NP, Karoli T, Blaskovich MAT, Cooper MA. Jarrad AM, et al. Among authors: west np. J Med Chem. 2018 Dec 27;61(24):11349-11371. doi: 10.1021/acs.jmedchem.8b01578. Epub 2018 Dec 11. J Med Chem. 2018. PMID: 30468386 Free PMC article.

8

Discovery, Synthesis and Evaluation of a Ketol-Acid Reductoisomerase Inhibitor.

Bayaraa T, Kurz JL, Patel KM, Hussein WM, Bilyj JK, West NP, Schenk G, McGeary RP, Guddat LW. Bayaraa T, et al. Among authors: west np. Chemistry. 2020 Jul 22;26(41):8958-8968. doi: 10.1002/chem.202000899. Epub 2020 Jul 1. Chemistry. 2020. PMID: 32198779

9

Structures of fungal and plant acetohydroxyacid synthases.

Lonhienne T, Low YS, Garcia MD, Croll T, Gao Y, Wang Q, Brillault L, Williams CM, Fraser JA, McGeary RP, West NP, Landsberg MJ, Rao Z, Schenk G, Guddat LW. Lonhienne T, et al. Among authors: west np. Nature. 2020 Oct;586(7828):317-321. doi: 10.1038/s41586-020-2514-3. Epub 2020 Jul 8. Nature. 2020. PMID: 32640464

10

Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility.

Ang CW, Tan L, Sykes ML, AbuGharbiyeh N, Debnath A, Reid JC, West NP, Avery VM, Cooper MA, Blaskovich MAT. Ang CW, et al. Among authors: west np. J Med Chem. 2020 Dec 24;63(24):15726-15751. doi: 10.1021/acs.jmedchem.0c01372. Epub 2020 Nov 5. J Med Chem. 2020. PMID: 33151678 Free PMC article.

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