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Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.
Drisaldi B, Coomaraswamy J, Mastrangelo P, Strome B, Yang J, Watts JC, Chishti MA, Marvi M, Windl O, Ahrens R, Major F, Sy MS, Kretzschmar H, Fraser PE, Mount HT, Westaway D. Drisaldi B, et al. Among authors: westaway d. J Biol Chem. 2004 Dec 31;279(53):55443-54. doi: 10.1074/jbc.M404794200. Epub 2004 Sep 29. J Biol Chem. 2004. PMID: 15459186 Free article.
Two homologous genes causing early-onset familial Alzheimer's disease.
St George-Hyslop PH, Levesque G, Levesque L, Rommens J, Westaway D, Fraser PE. St George-Hyslop PH, et al. Among authors: westaway d. Cold Spring Harb Symp Quant Biol. 1996;61:559-64. Cold Spring Harb Symp Quant Biol. 1996. PMID: 9246482 No abstract available.
The cellular prion protein binds copper in vivo.
Brown DR, Qin K, Herms JW, Madlung A, Manson J, Strome R, Fraser PE, Kruck T, von Bohlen A, Schulz-Schaeffer W, Giese A, Westaway D, Kretzschmar H. Brown DR, et al. Among authors: westaway d. Nature. 1997 Dec 18-25;390(6661):684-7. doi: 10.1038/37783. Nature. 1997. PMID: 9414160
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex.
Nishimura M, Yu G, Levesque G, Zhang DM, Ruel L, Chen F, Milman P, Holmes E, Liang Y, Kawarai T, Jo E, Supala A, Rogaeva E, Xu DM, Janus C, Levesque L, Bi Q, Duthie M, Rozmahel R, Mattila K, Lannfelt L, Westaway D, Mount HT, Woodgett J, St George-Hyslop P, et al. Nishimura M, et al. Among authors: westaway d. Nat Med. 1999 Feb;5(2):164-9. doi: 10.1038/5526. Nat Med. 1999. PMID: 9930863
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.
Moore RC, Lee IY, Silverman GL, Harrison PM, Strome R, Heinrich C, Karunaratne A, Pasternak SH, Chishti MA, Liang Y, Mastrangelo P, Wang K, Smit AF, Katamine S, Carlson GA, Cohen FE, Prusiner SB, Melton DW, Tremblay P, Hood LE, Westaway D. Moore RC, et al. Among authors: westaway d. J Mol Biol. 1999 Oct 1;292(4):797-817. doi: 10.1006/jmbi.1999.3108. J Mol Biol. 1999. PMID: 10525406
Transgenic mouse models of Alzheimer's disease.
Janus C, Chishti MA, Westaway D. Janus C, et al. Among authors: westaway d. Biochim Biophys Acta. 2000 Jul 26;1502(1):63-75. doi: 10.1016/s0925-4439(00)00033-8. Biochim Biophys Acta. 2000. PMID: 10899432 Free article. Review. No abstract available.
221 results