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Chemotype-selective modes of action of κ-opioid receptor agonists.
Vardy E, Mosier PD, Frankowski KJ, Wu H, Katritch V, Westkaemper RB, Aubé J, Stevens RC, Roth BL. Vardy E, et al. Among authors: Westkaemper RB. J Biol Chem. 2013 Nov 29;288(48):34470-83. doi: 10.1074/jbc.M113.515668. Epub 2013 Oct 11. J Biol Chem. 2013. PMID: 24121503 Free PMC article.
Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.
Vardy E, Sassano MF, Rennekamp AJ, Kroeze WK, Mosier PD, Westkaemper RB, Stevens CW, Katritch V, Stevens RC, Peterson RT, Roth BL. Vardy E, et al. Among authors: Westkaemper RB. Chem Biol. 2015 Jun 18;22(6):764-75. doi: 10.1016/j.chembiol.2015.05.012. Chem Biol. 2015. PMID: 26091169 Free PMC article.
Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists.
Li G, Aschenbach LC, Chen J, Cassidy MP, Stevens DL, Gabra BH, Selley DE, Dewey WL, Westkaemper RB, Zhang Y. Li G, et al. Among authors: Westkaemper RB. J Med Chem. 2009 Mar 12;52(5):1416-27. doi: 10.1021/jm801272c. J Med Chem. 2009. PMID: 19199782 Free PMC article.
Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation.
Runyon SP, Mosier PD, Roth BL, Glennon RA, Westkaemper RB. Runyon SP, et al. Among authors: Westkaemper RB. J Med Chem. 2008 Nov 13;51(21):6808-28. doi: 10.1021/jm800771x. Epub 2008 Oct 11. J Med Chem. 2008. PMID: 18847250 Free PMC article.
Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor.
Yan F, Bikbulatov RV, Mocanu V, Dicheva N, Parker CE, Wetsel WC, Mosier PD, Westkaemper RB, Allen JA, Zjawiony JK, Roth BL. Yan F, et al. Among authors: Westkaemper RB. Biochemistry. 2009 Jul 28;48(29):6898-908. doi: 10.1021/bi900605n. Biochemistry. 2009. PMID: 19555087 Free PMC article.
Structure of the human κ-opioid receptor in complex with JDTic.
Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC. Wu H, et al. Among authors: Westkaemper RB. Nature. 2012 Mar 21;485(7398):327-32. doi: 10.1038/nature10939. Nature. 2012. PMID: 22437504 Free PMC article.
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