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Rapamycin biosynthesis: Elucidation of gene product function.
Gregory MA, Hong H, Lill RE, Gaisser S, Petkovic H, Low L, Sheehan LS, Carletti I, Ready SJ, Ward MJ, Kaja AL, Weston AJ, Challis IR, Leadlay PF, Martin CJ, Wilkinson B, Sheridan RM. Gregory MA, et al. Among authors: weston aj. Org Biomol Chem. 2006 Oct 7;4(19):3565-8. doi: 10.1039/b608813a. Epub 2006 Aug 22. Org Biomol Chem. 2006. PMID: 16990929
Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272.
Gaisser S, Kellenberger L, Kaja AL, Weston AJ, Lill RE, Wirtz G, Kendrew SG, Low L, Sheridan RM, Wilkinson B, Galloway IS, Stutzman-Engwall K, McArthur HA, Staunton J, Leadlay PF. Gaisser S, et al. Among authors: weston aj. Org Biomol Chem. 2003 Aug 21;1(16):2840-7. doi: 10.1039/b304022d. Org Biomol Chem. 2003. PMID: 12968333
Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus.
Gregory MA, Gaisser S, Lill RE, Hong H, Sheridan RM, Wilkinson B, Petkovic H, Weston AJ, Carletti I, Lee HL, Staunton J, Leadlay PF. Gregory MA, et al. Among authors: weston aj. Angew Chem Int Ed Engl. 2004 May 3;43(19):2551-3. doi: 10.1002/anie.200453764. Angew Chem Int Ed Engl. 2004. PMID: 15127450 No abstract available.
24 results