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Gene modification strategies to induce tumor immunity.
Murphy A, Westwood JA, Teng MW, Moeller M, Darcy PK, Kershaw MH. Murphy A, et al. Among authors: westwood ja. Immunity. 2005 Apr;22(4):403-14. doi: 10.1016/j.immuni.2005.03.007. Immunity. 2005. PMID: 15845446 Review.
Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice.
Westwood JA, Smyth MJ, Teng MW, Moeller M, Trapani JA, Scott AM, Smyth FE, Cartwright GA, Power BE, Hönemann D, Prince HM, Darcy PK, Kershaw MH. Westwood JA, et al. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19051-6. doi: 10.1073/pnas.0504312102. Epub 2005 Dec 19. Proc Natl Acad Sci U S A. 2005. PMID: 16365285 Free PMC article.
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer.
Kershaw MH, Westwood JA, Parker LL, Wang G, Eshhar Z, Mavroukakis SA, White DE, Wunderlich JR, Canevari S, Rogers-Freezer L, Chen CC, Yang JC, Rosenberg SA, Hwu P. Kershaw MH, et al. Among authors: westwood ja. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6106-15. doi: 10.1158/1078-0432.CCR-06-1183. Clin Cancer Res. 2006. PMID: 17062687 Free PMC article. Clinical Trial.
Interleukin 21 enhances antibody-mediated tumor rejection.
Smyth MJ, Teng MW, Sharkey J, Westwood JA, Haynes NM, Yagita H, Takeda K, Sivakumar PV, Kershaw MH. Smyth MJ, et al. Among authors: westwood ja. Cancer Res. 2008 Apr 15;68(8):3019-25. doi: 10.1158/0008-5472.CAN-07-6019. Cancer Res. 2008. PMID: 18413772
The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum.
Westwood JA, Murray WK, Trivett M, Haynes NM, Solomon B, Mileshkin L, Ball D, Michael M, Burman A, Mayura-Guru P, Trapani JA, Peinert S, Hönemann D, Miles Prince H, Scott AM, Smyth MJ, Darcy PK, Kershaw MH. Westwood JA, et al. J Immunother. 2009 Apr;32(3):292-301. doi: 10.1097/CJI.0b013e31819b7c8e. J Immunother. 2009. PMID: 19242371
Genetic redirection of T cells for cancer therapy.
Westwood JA, Kershaw MH. Westwood JA, et al. J Leukoc Biol. 2010 May;87(5):791-803. doi: 10.1189/jlb.1209824. Epub 2010 Feb 23. J Leukoc Biol. 2010. PMID: 20179152 Review.
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