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Assessing disease onset and progression in the SOD1 mouse model of ALS.
Weydt P, Hong SY, Kliot M, Möller T. Weydt P, et al. Neuroreport. 2003 May 23;14(7):1051-4. doi: 10.1097/01.wnr.0000073685.00308.89. Neuroreport. 2003. PMID: 12802201
Evaluation of monoacylglycerol lipase as a therapeutic target in a transgenic mouse model of ALS.
Pasquarelli N, Engelskirchen M, Hanselmann J, Endres S, Porazik C, Bayer H, Buck E, Karsak M, Weydt P, Ferger B, Witting A. Pasquarelli N, et al. Neuropharmacology. 2017 Sep 15;124:157-169. doi: 10.1016/j.neuropharm.2017.03.037. Epub 2017 Mar 31. Neuropharmacology. 2017. PMID: 28373073
PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis.
Eschbach J, Schwalenstöcker B, Soyal SM, Bayer H, Wiesner D, Akimoto C, Nilsson AC, Birve A, Meyer T, Dupuis L, Danzer KM, Andersen PM, Witting A, Ludolph AC, Patsch W, Weydt P. Eschbach J, et al. Hum Mol Genet. 2013 Sep 1;22(17):3477-84. doi: 10.1093/hmg/ddt202. Epub 2013 May 12. Hum Mol Genet. 2013. PMID: 23669350
The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease.
Weydt P, Soyal SM, Gellera C, Didonato S, Weidinger C, Oberkofler H, Landwehrmeyer GB, Patsch W. Weydt P, et al. Mol Neurodegener. 2009 Jan 8;4:3. doi: 10.1186/1750-1326-4-3. Mol Neurodegener. 2009. PMID: 19133136 Free PMC article.
Incidence and geographical variation of amyotrophic lateral sclerosis (ALS) in Southern Germany--completeness of the ALS registry Swabia.
Uenal H, Rosenbohm A, Kufeldt J, Weydt P, Goder K, Ludolph A, Rothenbacher D, Nagel G; ALS registry Study Group. Uenal H, et al. PLoS One. 2014 Apr 10;9(4):e93932. doi: 10.1371/journal.pone.0093932. eCollection 2014. PLoS One. 2014. PMID: 24722455 Free PMC article.
High SIR suggesting geographical clusters were observed in two counties (Göppingen and Bodenseekreis), but the variation was not statistically significant (p-values = 0.2 and 0.5). ...
High SIR suggesting geographical clusters were observed in two counties (Göppingen and Bodenseekreis), but the variation was not statistical …
A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort.
Weydt P, Soyal SM, Landwehrmeyer GB, Patsch W; European Huntington Disease Network. Weydt P, et al. BMC Neurol. 2014 Jan 2;14:1. doi: 10.1186/1471-2377-14-1. BMC Neurol. 2014. PMID: 24383721 Free PMC article.
ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues.
Bayer H, Lang K, Buck E, Higelin J, Barteczko L, Pasquarelli N, Sprissler J, Lucas T, Holzmann K, Demestre M, Lindenberg KS, Danzer KM, Boeckers T, Ludolph AC, Dupuis L, Weydt P, Witting A. Bayer H, et al. Neurobiol Dis. 2017 Jan;97(Pt A):36-45. doi: 10.1016/j.nbd.2016.11.001. Epub 2016 Nov 3. Neurobiol Dis. 2017. PMID: 27818323
Peripheral monocytes are functionally altered and invade the CNS in ALS patients.
Zondler L, Müller K, Khalaji S, Bliederhäuser C, Ruf WP, Grozdanov V, Thiemann M, Fundel-Clemes K, Freischmidt A, Holzmann K, Strobel B, Weydt P, Witting A, Thal DR, Helferich AM, Hengerer B, Gottschalk KE, Hill O, Kluge M, Ludolph AC, Danzer KM, Weishaupt JH. Zondler L, et al. Acta Neuropathol. 2016 Sep;132(3):391-411. doi: 10.1007/s00401-016-1548-y. Epub 2016 Feb 24. Acta Neuropathol. 2016. PMID: 26910103
Drug therapy for amyotrophic lateral sclerosis: Where are we now?
Carter GT, Krivickas LS, Weydt P, Weiss MD, Miller RG. Carter GT, et al. IDrugs. 2003 Feb;6(2):147-53. IDrugs. 2003. PMID: 12789618 Review.
Neuro-inflammation as a therapeutic target in amyotrophic lateral sclerosis.
Weydt P, Weiss MD, Möller T, Carter GT. Weydt P, et al. Curr Opin Investig Drugs. 2002 Dec;3(12):1720-4. Curr Opin Investig Drugs. 2002. PMID: 12528305 Review.
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