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Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
Foster SA, Whalen DM, Özen A, Wongchenko MJ, Yin J, Yen I, Schaefer G, Mayfield JD, Chmielecki J, Stephens PJ, Albacker LA, Yan Y, Song K, Hatzivassiliou G, Eigenbrot C, Yu C, Shaw AS, Manning G, Skelton NJ, Hymowitz SG, Malek S. Foster SA, et al. Among authors: whalen dm. Cancer Cell. 2016 Apr 11;29(4):477-493. doi: 10.1016/j.ccell.2016.02.010. Epub 2016 Mar 17. Cancer Cell. 2016. PMID: 26996308 Free article.
Kinase domain dimerization drives RIPK3-dependent necroptosis.
Raju S, Whalen DM, Mengistu M, Swanson C, Quinn JG, Taylor SS, Webster JD, Newton K, Shaw AS. Raju S, et al. Among authors: whalen dm. Sci Signal. 2018 Aug 21;11(544):eaar2188. doi: 10.1126/scisignal.aar2188. Sci Signal. 2018. PMID: 30131368 Free PMC article.
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS.
Schulze CJ, Seamon KJ, Zhao Y, Yang YC, Cregg J, Kim D, Tomlinson A, Choy TJ, Wang Z, Sang B, Pourfarjam Y, Lucas J, Cuevas-Navarro A, Ayala-Santos C, Vides A, Li C, Marquez A, Zhong M, Vemulapalli V, Weller C, Gould A, Whalen DM, Salvador A, Milin A, Saldajeno-Concar M, Dinglasan N, Chen A, Evans J, Knox JE, Koltun ES, Singh M, Nichols R, Wildes D, Gill AL, Smith JAM, Lito P. Schulze CJ, et al. Among authors: whalen dm. Science. 2023 Aug 18;381(6659):794-799. doi: 10.1126/science.adg9652. Epub 2023 Aug 17. Science. 2023. PMID: 37590355 Free PMC article.
Structural insights into proteoglycan-shaped Hedgehog signaling.
Whalen DM, Malinauskas T, Gilbert RJ, Siebold C. Whalen DM, et al. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16420-5. doi: 10.1073/pnas.1310097110. Epub 2013 Sep 23. Proc Natl Acad Sci U S A. 2013. PMID: 24062467 Free PMC article.