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Chemotherapy-induced cachexia dysregulates hypothalamic and systemic lipoamines and is attenuated by cannabigerol.
Brierley DI, Harman JR, Giallourou N, Leishman E, Roashan AE, Mellows BAD, Bradshaw HB, Swann JR, Patel K, Whalley BJ, Williams CM. Brierley DI, et al. Among authors: whalley bj. J Cachexia Sarcopenia Muscle. 2019 Aug;10(4):844-859. doi: 10.1002/jcsm.12426. Epub 2019 Apr 29. J Cachexia Sarcopenia Muscle. 2019. PMID: 31035309 Free PMC article. Clinical Trial.
Species-specific susceptibility to cannabis-induced convulsions.
Whalley BJ, Lin H, Bell L, Hill T, Patel A, Gray RA, Elizabeth Roberts C, Devinsky O, Bazelot M, Williams CM, Stephens GJ. Whalley BJ, et al. Br J Pharmacol. 2019 May;176(10):1506-1523. doi: 10.1111/bph.14165. Epub 2018 Mar 25. Br J Pharmacol. 2019. PMID: 29457829 Free PMC article.
Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se.
Hill AJ, Jones NA, Smith I, Hill CL, Williams CM, Stephens GJ, Whalley BJ. Hill AJ, et al. Neurosci Lett. 2014 Apr 30;566:269-74. doi: 10.1016/j.neulet.2014.03.013. Epub 2014 Mar 16. Neurosci Lett. 2014. PMID: 24642454
The cannabinoid CB2 receptor-specific agonist AM1241 increases pentylenetetrazole-induced seizure severity in Wistar rats.
de Carvalho CR, Hoeller AA, Franco PL, Martini AP, Soares FM, Lin K, Prediger RD, Whalley BJ, Walz R. de Carvalho CR, et al. Epilepsy Res. 2016 Nov;127:160-167. doi: 10.1016/j.eplepsyres.2016.08.011. Epub 2016 Aug 29. Epilepsy Res. 2016. PMID: 27608434
Cannabinoids and Epilepsy.
Rosenberg EC, Tsien RW, Whalley BJ, Devinsky O. Rosenberg EC, et al. Neurotherapeutics. 2015 Oct;12(4):747-68. doi: 10.1007/s13311-015-0375-5. Neurotherapeutics. 2015. PMID: 26282273 Free PMC article. Review.
Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.
Jones NA, Glyn SE, Akiyama S, Hill TD, Hill AJ, Weston SE, Burnett MD, Yamasaki Y, Stephens GJ, Whalley BJ, Williams CM. Jones NA, et al. Seizure. 2012 Jun;21(5):344-52. doi: 10.1016/j.seizure.2012.03.001. Epub 2012 Apr 19. Seizure. 2012. PMID: 22520455
Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats.
Brierley DI, Samuels J, Duncan M, Whalley BJ, Williams CM. Brierley DI, et al. Psychopharmacology (Berl). 2016 Oct;233(19-20):3603-13. doi: 10.1007/s00213-016-4397-4. Epub 2016 Aug 9. Psychopharmacology (Berl). 2016. PMID: 27503475 Free PMC article.
Cannabis constituents modulate δ9-tetrahydrocannabinol-induced hyperphagia in rats.
Farrimond JA, Hill AJ, Whalley BJ, Williams CM. Farrimond JA, et al. Psychopharmacology (Berl). 2010 May;210(1):97-106. doi: 10.1007/s00213-010-1821-z. Epub 2010 Mar 27. Psychopharmacology (Berl). 2010. PMID: 20349049
Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.
Jones NA, Hill AJ, Smith I, Bevan SA, Williams CM, Whalley BJ, Stephens GJ. Jones NA, et al. J Pharmacol Exp Ther. 2010 Feb;332(2):569-77. doi: 10.1124/jpet.109.159145. Epub 2009 Nov 11. J Pharmacol Exp Ther. 2010. PMID: 19906779 Free PMC article.
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