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Signal transduction by wild-type and leukemogenic Abl proteins.
Raitano AB, Whang YE, Sawyers CL. Raitano AB, et al. Biochim Biophys Acta. 1997 Dec 9;1333(3):F201-16. doi: 10.1016/s0304-419x(97)00023-1. Biochim Biophys Acta. 1997. PMID: 9426204 Review. No abstract available.
c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency.
Whang YE, Tran C, Henderson C, Syljuasen RG, Rozengurt N, McBride WH, Sawyers CL. Whang YE, et al. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5486-91. doi: 10.1073/pnas.97.10.5486. Proc Natl Acad Sci U S A. 2000. PMID: 10805805 Free PMC article.
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.
Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL. Wu X, et al. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15587-91. doi: 10.1073/pnas.95.26.15587. Proc Natl Acad Sci U S A. 1998. PMID: 9861013 Free PMC article.
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression.
Whang YE, Wu X, Suzuki H, Reiter RE, Tran C, Vessella RL, Said JW, Isaacs WB, Sawyers CL. Whang YE, et al. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5246-50. doi: 10.1073/pnas.95.9.5246. Proc Natl Acad Sci U S A. 1998. PMID: 9560261 Free PMC article.
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2.
Wu X, Hepner K, Castelino-Prabhu S, Do D, Kaye MB, Yuan XJ, Wood J, Ross C, Sawyers CL, Whang YE. Wu X, et al. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4233-8. doi: 10.1073/pnas.97.8.4233. Proc Natl Acad Sci U S A. 2000. PMID: 10760291 Free PMC article.
Role for c-Abl tyrosine kinase in growth arrest response to DNA damage.
Yuan ZM, Huang Y, Whang Y, Sawyers C, Weichselbaum R, Kharbanda S, Kufe D. Yuan ZM, et al. Nature. 1996 Jul 18;382(6588):272-4. doi: 10.1038/382272a0. Nature. 1996. PMID: 8717045
Functional role for the c-Abl tyrosine kinase in meiosis I.
Kharbanda S, Pandey P, Morris PL, Whang Y, Xu Y, Sawant S, Zhu LJ, Kumar N, Yuan ZM, Weichselbaum R, Sawyers CL, Pandita TK, Kufe D. Kharbanda S, et al. Oncogene. 1998 Apr 9;16(14):1773-7. doi: 10.1038/sj.onc.1201934. Oncogene. 1998. PMID: 9583675
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