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35 results
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Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy.
Warner TD, Nylander S, Whatling C. Warner TD, et al. Among authors: whatling c. Br J Clin Pharmacol. 2011 Oct;72(4):619-33. doi: 10.1111/j.1365-2125.2011.03943.x. Br J Clin Pharmacol. 2011. PMID: 21320154 Free PMC article. Review.
Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase I study in healthy volunteers.
Gan LM, Lagerström-Fermér M, Ericsson H, Nelander K, Lindstedt EL, Michaëlsson E, Kjaer M, Heijer M, Whatling C, Fuhr R. Gan LM, et al. Among authors: whatling c. Br J Clin Pharmacol. 2019 Apr;85(4):762-770. doi: 10.1111/bcp.13855. Epub 2019 Feb 18. Br J Clin Pharmacol. 2019. PMID: 30618054 Free PMC article. Clinical Trial.
Initial Clinical Experience with AZD5718, a Novel Once Daily Oral 5-Lipoxygenase Activating Protein Inhibitor.
Ericsson H, Nelander K, Lagerstrom-Fermer M, Balendran C, Bhat M, Chialda L, Gan LM, Heijer M, Kjaer M, Lambert J, Lindstedt EL, Forsberg GB, Whatling C, Skrtic S. Ericsson H, et al. Among authors: whatling c. Clin Transl Sci. 2018 May;11(3):330-338. doi: 10.1111/cts.12546. Epub 2018 Mar 8. Clin Transl Sci. 2018. PMID: 29517132 Free PMC article. Clinical Trial.
Ticagrelor Removal From Human Blood.
Angheloiu GO, Gugiu GB, Ruse C, Pandey R, Dasari RR, Whatling C. Angheloiu GO, et al. Among authors: whatling c. JACC Basic Transl Sci. 2017 Apr 24;2(2):135-145. doi: 10.1016/j.jacbts.2017.01.007. eCollection 2017 Apr. JACC Basic Transl Sci. 2017. PMID: 30167561 Free PMC article.
Recent advances for FLAP inhibitors.
Pettersen D, Davidsson Ö, Whatling C. Pettersen D, et al. Among authors: whatling c. Bioorg Med Chem Lett. 2015 Jul 1;25(13):2607-12. doi: 10.1016/j.bmcl.2015.04.090. Epub 2015 May 6. Bioorg Med Chem Lett. 2015. PMID: 26004579 Review.
Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.
Pettersen D, Broddefalk J, Emtenäs H, Hayes MA, Lemurell M, Swanson M, Ulander J, Whatling C, Amilon C, Ericsson H, Westin Eriksson A, Granberg K, Plowright AT, Shamovsky I, Dellsèn A, Sundqvist M, Någård M, Lindstedt EL. Pettersen D, et al. Among authors: whatling c. J Med Chem. 2019 May 9;62(9):4312-4324. doi: 10.1021/acs.jmedchem.8b02004. Epub 2019 Mar 26. J Med Chem. 2019. PMID: 30869888
Highly sensitive and specific LC-MS/MS method to determine endogenous leukotriene B4 levels in human plasma.
Bhat M, Lindgren A, Eketjäll S, Hidi R, Schatz P, Whatling C, Fidock M. Bhat M, et al. Among authors: whatling c. Bioanalysis. 2019 Jun;11(11):1055-1066. doi: 10.4155/bio-2019-0021. Bioanalysis. 2019. PMID: 31251101
The potential link between atherosclerosis and the 5-lipoxygenase pathway: investigational agents with new implications for the cardiovascular field.
Whatling C, McPheat W, Herslöf M. Whatling C, et al. Expert Opin Investig Drugs. 2007 Dec;16(12):1879-93. doi: 10.1517/13543784.16.12.1879. Expert Opin Investig Drugs. 2007. PMID: 18041998 Review.
Novel Chemical Series of 5-Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease.
Lemurell M, Ulander J, Emtenäs H, Winiwarter S, Broddefalk J, Swanson M, Hayes MA, Prieto Garcia L, Westin Eriksson A, Meuller J, Cassel J, Saarinen G, Yuan ZQ, Löfberg C, Karlsson S, Sundqvist M, Whatling C. Lemurell M, et al. Among authors: whatling c. J Med Chem. 2019 May 9;62(9):4325-4349. doi: 10.1021/acs.jmedchem.8b02012. Epub 2019 Apr 15. J Med Chem. 2019. PMID: 30929436
Discovery of AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP) for the treatment of inflammatory diseases.
Lemurell M, Ulander J, Winiwarter S, Dahlén A, Davidsson Ö, Emtenäs H, Broddefalk J, Swanson M, Hovdal D, Plowright AT, Pettersen A, Rydén-Landergren M, Barlind J, Llinas A, Herslöf M, Drmota T, Sigfridsson K, Moses S, Whatling C. Lemurell M, et al. Among authors: whatling c. J Med Chem. 2015 Jan 22;58(2):897-911. doi: 10.1021/jm501531v. Epub 2014 Dec 22. J Med Chem. 2015. PMID: 25478788
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