Wheelhouse RT - Search Results

1

Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials.

Newlands ES, Stevens MF, Wedge SR, Wheelhouse RT, Brock C. Newlands ES, et al. Among authors: wheelhouse rt. Cancer Treat Rev. 1997 Jan;23(1):35-61. doi: 10.1016/s0305-7372(97)90019-0. Cancer Treat Rev. 1997. PMID: 9189180 Review. No abstract available.

2

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth.

Ramirez YP, Mladek AC, Phillips RM, Gynther M, Rautio J, Ross AH, Wheelhouse RT, Sakaria JN. Ramirez YP, et al. Among authors: wheelhouse rt. Mol Cancer Ther. 2015 Jan;14(1):111-9. doi: 10.1158/1535-7163.MCT-14-0113. Epub 2014 Oct 28. Mol Cancer Ther. 2015. PMID: 25351918 Free PMC article.

3

Minor structural modifications to alchemix influence mechanism of action and pharmacological activity.

Abdallah QM, Phillips RM, Johansson F, Helleday T, Cosentino L, Abdel-Rahman H, Etzad J, Wheelhouse RT, Kiakos K, Bingham JP, Hartley JA, Patterson LH, Pors K. Abdallah QM, et al. Among authors: wheelhouse rt. Biochem Pharmacol. 2012 Jun 1;83(11):1514-22. doi: 10.1016/j.bcp.2012.02.017. Epub 2012 Mar 1. Biochem Pharmacol. 2012. PMID: 22387433

4

Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.

Pletsas D, Garelnabi EA, Li L, Phillips RM, Wheelhouse RT. Pletsas D, et al. Among authors: wheelhouse rt. J Med Chem. 2013 Sep 12;56(17):7120-32. doi: 10.1021/jm401121k. Epub 2013 Aug 16. J Med Chem. 2013. PMID: 23895620 Free PMC article.

5

Polar, functionalized guanine-O6 derivatives resistant to repair by O6-alkylguanine-DNA alkyltransferase: implications for the design of DNA-modifying drugs.

Pletsas D, Wheelhouse RT, Pletsa V, Nicolaou A, Jenkins TC, Bibby MC, Kyrtopoulos SA. Pletsas D, et al. Among authors: wheelhouse rt. Eur J Med Chem. 2006 Mar;41(3):330-9. doi: 10.1016/j.ejmech.2005.11.007. Epub 2006 Feb 3. Eur J Med Chem. 2006. PMID: 16458393

6

Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands.

Allison SJ, Sadiq M, Baronou E, Cooper PA, Dunnill C, Georgopoulos NT, Latif A, Shepherd S, Shnyder SD, Stratford IJ, Wheelhouse RT, Willans CE, Phillips RM. Allison SJ, et al. Among authors: wheelhouse rt. Cancer Lett. 2017 Sep 10;403:98-107. doi: 10.1016/j.canlet.2017.04.041. Epub 2017 Jun 15. Cancer Lett. 2017. PMID: 28624622 Free article.

7

Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR.

Garelnabi EA, Pletsas D, Li L, Kiakos K, Karodia N, Hartley JA, Phillips RM, Wheelhouse RT. Garelnabi EA, et al. Among authors: wheelhouse rt. ACS Med Chem Lett. 2012 Sep 18;3(12):965-8. doi: 10.1021/ml300132t. eCollection 2012 Dec 13. ACS Med Chem Lett. 2012. PMID: 24900418 Free PMC article.

8

Glioblastoma multiforme therapy and mechanisms of resistance.

Ramirez YP, Weatherbee JL, Wheelhouse RT, Ross AH. Ramirez YP, et al. Among authors: wheelhouse rt. Pharmaceuticals (Basel). 2013 Nov 25;6(12):1475-506. doi: 10.3390/ph6121475. Pharmaceuticals (Basel). 2013. PMID: 24287492 Free PMC article.

9

The medicinal chemistry of imidazotetrazine prodrugs.

Moody CL, Wheelhouse RT. Moody CL, et al. Among authors: wheelhouse rt. Pharmaceuticals (Basel). 2014 Jul 10;7(7):797-838. doi: 10.3390/ph7070797. Pharmaceuticals (Basel). 2014. PMID: 25014631 Free PMC article.

10

Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate.

Holley JL, Mather A, Wheelhouse RT, Cullis PM, Hartley JA, Bingham JP, Cohen GM. Holley JL, et al. Among authors: wheelhouse rt. Cancer Res. 1992 Aug 1;52(15):4190-5. Cancer Res. 1992. PMID: 1638533

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