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T cell exhaustion.
Wherry EJ. Wherry EJ. Nat Immunol. 2011 Jun;12(6):492-9. doi: 10.1038/ni.2035. Nat Immunol. 2011. PMID: 21739672 Review.
The induction of virus-specific CTL as a function of increasing epitope expression: responses rise steadily until excessively high levels of epitope are attained.
Wherry EJ, Puorro KA, Porgador A, Eisenlohr LC. Wherry EJ, et al. J Immunol. 1999 Oct 1;163(7):3735-45. J Immunol. 1999. PMID: 10490969
Efficient and qualitatively distinct MHC class I-restricted presentation of antigen targeted to the endoplasmic reticulum.
Golovina TN, Wherry EJ, Bullock TN, Eisenlohr LC. Golovina TN, et al. Among authors: wherry ej. J Immunol. 2002 Mar 15;168(6):2667-75. doi: 10.4049/jimmunol.168.6.2667. J Immunol. 2002. PMID: 11884431
Generation of CD8(+) T cell memory in response to low, high, and excessive levels of epitope.
Wherry EJ, McElhaugh MJ, Eisenlohr LC. Wherry EJ, et al. J Immunol. 2002 May 1;168(9):4455-61. doi: 10.4049/jimmunol.168.9.4455. J Immunol. 2002. PMID: 11970989
Effector and memory T-cell differentiation: implications for vaccine development.
Kaech SM, Wherry EJ, Ahmed R. Kaech SM, et al. Among authors: wherry ej. Nat Rev Immunol. 2002 Apr;2(4):251-62. doi: 10.1038/nri778. Nat Rev Immunol. 2002. PMID: 12001996 Review.
Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells.
Becker TC, Wherry EJ, Boone D, Murali-Krishna K, Antia R, Ma A, Ahmed R. Becker TC, et al. Among authors: wherry ej. J Exp Med. 2002 Jun 17;195(12):1541-8. doi: 10.1084/jem.20020369. J Exp Med. 2002. PMID: 12070282 Free PMC article.
Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo.
Grayson JM, Harrington LE, Lanier JG, Wherry EJ, Ahmed R. Grayson JM, et al. Among authors: wherry ej. J Immunol. 2002 Oct 1;169(7):3760-70. doi: 10.4049/jimmunol.169.7.3760. J Immunol. 2002. PMID: 12244170
Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha.
Wherry EJ, Becker TC, Boone D, Kaja MK, Ma A, Ahmed R. Wherry EJ, et al. Adv Exp Med Biol. 2002;512:165-75. doi: 10.1007/978-1-4615-0757-4_22. Adv Exp Med Biol. 2002. PMID: 12405201
Lineage relationship and protective immunity of memory CD8 T cell subsets.
Wherry EJ, Teichgräber V, Becker TC, Masopust D, Kaech SM, Antia R, von Andrian UH, Ahmed R. Wherry EJ, et al. Nat Immunol. 2003 Mar;4(3):225-34. doi: 10.1038/ni889. Epub 2003 Feb 3. Nat Immunol. 2003. PMID: 12563257
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment.
Wherry EJ, Blattman JN, Murali-Krishna K, van der Most R, Ahmed R. Wherry EJ, et al. J Virol. 2003 Apr;77(8):4911-27. doi: 10.1128/jvi.77.8.4911-4927.2003. J Virol. 2003. PMID: 12663797 Free PMC article.