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2005 1
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2009 6
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139 results

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Page 1
Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape.
Omo-Lamai S, Wang Y, Patel MN, Milosavljevic A, Zuschlag D, Poddar S, Wu J, Wang L, Dong F, Espy C, Majumder A, Essien EO, Shen M, Channer B, Papp TE, Tobin M, Maheshwari R, Jeong S, Patel S, Shah A, Murali S, Chase LS, Zamora ME, Arral ML, Marcos-Contreras OA, Myerson JW, Hunter CA, Discher D, Gaskill PJ, Tsourkas A, Muzykantov VR, Brodsky I, Shin S, Whitehead KA, Parhiz H, Katzen J, Miner JJ, Trauner D, Brenner JS. Omo-Lamai S, et al. Among authors: whitehead ka. Nat Nanotechnol. 2025 Sep;20(9):1285-1297. doi: 10.1038/s41565-025-01974-5. Epub 2025 Aug 11. Nat Nanotechnol. 2025. PMID: 40789922 Free PMC article.
Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d.
Chaudhary N, Kasiewicz LN, Newby AN, Arral ML, Yerneni SS, Melamed JR, LoPresti ST, Fein KC, Strelkova Petersen DM, Kumar S, Purwar R, Whitehead KA. Chaudhary N, et al. Among authors: whitehead ka. Nat Biomed Eng. 2024 Nov;8(11):1483-1498. doi: 10.1038/s41551-024-01256-w. Epub 2024 Oct 3. Nat Biomed Eng. 2024. PMID: 39363106 Free PMC article.
Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects.
Omo-Lamai S, Wang Y, Patel MN, Essien EO, Shen M, Majumdar A, Espy C, Wu J, Channer B, Tobin M, Murali S, Papp TE, Maheshwari R, Wang L, Chase LS, Zamora ME, Arral ML, Marcos-Contreras OA, Myerson JW, Hunter CA, Tsourkas A, Muzykantov V, Brodsky I, Shin S, Whitehead KA, Gaskill P, Discher D, Parhiz H, Brenner JS. Omo-Lamai S, et al. Among authors: whitehead ka. bioRxiv [Preprint]. 2024 Apr 18:2024.04.16.589801. doi: 10.1101/2024.04.16.589801. bioRxiv. 2024. PMID: 38659905 Free PMC article. Preprint.
A translational framework to DELIVER nanomedicines to the clinic.
Joyce P, Allen CJ, Alonso MJ, Ashford M, Bradbury MS, Germain M, Kavallaris M, Langer R, Lammers T, Peracchia MT, Popat A, Prestidge CA, Rijcken CJF, Sarmento B, Schmid RB, Schroeder A, Subramaniam S, Thorn CR, Whitehead KA, Zhao CX, Santos HA. Joyce P, et al. Among authors: whitehead ka. Nat Nanotechnol. 2024 Nov;19(11):1597-1611. doi: 10.1038/s41565-024-01754-7. Epub 2024 Sep 6. Nat Nanotechnol. 2024. PMID: 39242807 Review.
Polyamine biomarkers as indicators of human disease.
Amin M, Tang S, Shalamanova L, Taylor RL, Wylie S, Abdullah BM, Whitehead KA. Amin M, et al. Among authors: whitehead ka. Biomarkers. 2021 Mar;26(2):77-94. doi: 10.1080/1354750X.2021.1875506. Epub 2021 Jan 25. Biomarkers. 2021. PMID: 33439737 Review.
139 results