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Impaired activation of phosphoinositide 3-kinase by insulin in fibroblasts from patients with severe insulin resistance and pseudoacromegaly. A disorder characterized by selective postreceptor insulin resistance.
Dib K, Whitehead JP, Humphreys PJ, Soos MA, Baynes KC, Kumar S, Harvey T, O'Rahilly S. Dib K, et al. Among authors: whitehead jp. J Clin Invest. 1998 Mar 1;101(5):1111-20. doi: 10.1172/JCI119884. J Clin Invest. 1998. PMID: 9486982 Free PMC article.
Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects.
Krook A, Whitehead JP, Dobson SP, Griffiths MR, Ouwens M, Baker C, Hayward AC, Sen SK, Maassen JA, Siddle K, Tavaré JM, O'Rahilly S. Krook A, et al. Among authors: whitehead jp. J Biol Chem. 1997 Nov 28;272(48):30208-14. doi: 10.1074/jbc.272.48.30208. J Biol Chem. 1997. PMID: 9374504 Free article.
110 results