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Differentiating developmental outcome between infants with severe disability in research studies: the role of Bayley Developmental Quotients.
Jary S, Kmita G, Whitelaw A. Jary S, et al. Among authors: whitelaw a. J Pediatr. 2011 Aug;159(2):211-4.e1. doi: 10.1016/j.jpeds.2011.01.037. Epub 2011 Mar 10. J Pediatr. 2011. PMID: 21392784
OBJECTIVES: To investigate whether infants with a score <50 on the Bayley Scales of Infant Development, Second Edition (BSID-II) demonstrated differences in functional ability, and to assess whether the Bayley Developmental Quotients (DQs) indicated such differences. .. …
OBJECTIVES: To investigate whether infants with a score <50 on the Bayley Scales of Infant Development, Second Edition (BSID-II) d …
Resuscitation at birth and cognition at 8 years of age: a cohort study.
Odd DE, Lewis G, Whitelaw A, Gunnell D. Odd DE, et al. Among authors: whitelaw a. Lancet. 2009 May 9;373(9675):1615-22. doi: 10.1016/S0140-6736(09)60244-0. Epub 2009 Apr 20. Lancet. 2009. PMID: 19386357 Free PMC article.
Cognitive function was assessed at a mean age of 8.6 years (SD 0.33); a low IQ score was defined as less than 80. IQ scores were obtained for 5953 children with a shortened version of the Weschler intelligence scale for children (WISC-III), the remaining 5529 …
Cognitive function was assessed at a mean age of 8.6 years (SD 0.33); a low IQ score was defined as less than 80. IQ scores we …
Effects of hypothermia for perinatal asphyxia on childhood outcomes.
Azzopardi D, Strohm B, Marlow N, Brocklehurst P, Deierl A, Eddama O, Goodwin J, Halliday HL, Juszczak E, Kapellou O, Levene M, Linsell L, Omar O, Thoresen M, Tusor N, Whitelaw A, Edwards AD; TOBY Study Group. Azzopardi D, et al. Among authors: whitelaw a. N Engl J Med. 2014 Jul 10;371(2):140-9. doi: 10.1056/NEJMoa1315788. N Engl J Med. 2014. PMID: 25006720 Clinical Trial.
METHODS: We randomly assigned 325 newborns with asphyxial encephalopathy who were born at a gestational age of 36 weeks or more to receive standard care alone (control) or standard care with hypothermia to a rectal temperature of 33 to 34°C for 72 hours within 6 hou …
METHODS: We randomly assigned 325 newborns with asphyxial encephalopathy who were born at a gestational age of 36 weeks or more to re …
Comparison of Bayley-2 and Bayley-3 scores at 18 months in term infants following neonatal encephalopathy and therapeutic hypothermia.
Jary S, Whitelaw A, Walløe L, Thoresen M. Jary S, et al. Among authors: whitelaw a. Dev Med Child Neurol. 2013 Nov;55(11):1053-9. doi: 10.1111/dmcn.12208. Epub 2013 Aug 9. Dev Med Child Neurol. 2013. PMID: 23927586 Free PMC article.
Ten children had a Bayley-2 MDI of <70; only three children had Bayley-3 combined Cognitive/Language scores of <70. Eleven children had Bayley-2 PDI scores of <70 and four had modified Bayley-3 Motor Composite scores of <70. ...
Ten children had a Bayley-2 MDI of <70; only three children had Bayley-3 combined Cognitive/Language scores of <70. Eleven chil …
Cerebral Resistance Index is less predictive in hypothermic encephalopathic newborns.
Elstad M, Whitelaw A, Thoresen M. Elstad M, et al. Among authors: whitelaw a. Acta Paediatr. 2011 Oct;100(10):1344-9. doi: 10.1111/j.1651-2227.2011.02327.x. Epub 2011 May 18. Acta Paediatr. 2011. PMID: 21517959
In HIE, Pourcelot's cerebral vascular resistance index (RI) below 0.55 (by Doppler ultrasound) from published literature at normothermia predicted poor outcome with a positive predictive value (PPV) of 84%. ...The lower PPV may be because hypothermia affects cerebral vascu …
In HIE, Pourcelot's cerebral vascular resistance index (RI) below 0.55 (by Doppler ultrasound) from published literature at normothermia pre …
Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data.
Edwards AD, Brocklehurst P, Gunn AJ, Halliday H, Juszczak E, Levene M, Strohm B, Thoresen M, Whitelaw A, Azzopardi D. Edwards AD, et al. Among authors: whitelaw a. BMJ. 2010 Feb 9;340:c363. doi: 10.1136/bmj.c363. BMJ. 2010. PMID: 20144981 Free PMC article.
DESIGN: A meta-analysis was performed using a fixed effect model. Risk ratios, risk difference, and number needed to treat, plus 95% confidence intervals, were measured. ...CONCLUSIONS: In infants with hypoxic-ischaemic encephalopathy, moderate hypothermia is associ …
DESIGN: A meta-analysis was performed using a fixed effect model. Risk ratios, risk difference, and number needed to treat, pl …
Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy.
Gunn AJ, Wyatt JS, Whitelaw A, Barks J, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, Gluckman PD, Polin RA, Robertson CM, Thoresen M; CoolCap Study Group. Gunn AJ, et al. Among authors: whitelaw a. J Pediatr. 2008 Jan;152(1):55-8, 58.e1. doi: 10.1016/j.jpeds.2007.06.003. Epub 2007 Oct 24. J Pediatr. 2008. PMID: 18154900 Clinical Trial.
STUDY DESIGN: This study was a secondary analysis of a multicenter study of 234 term infants with neonatal encephalopathy randomized to head cooling for 72 hours starting within 6 hours of birth, with rectal temperature maintained at 34.5 degrees C +/- 0.5 degrees C …
STUDY DESIGN: This study was a secondary analysis of a multicenter study of 234 term infants with neonatal encephalopathy rand …
Quantitative cranial ultrasound prediction of severity of disability in premature infants with post-haemorrhagic ventricular dilatation.
Jary S, Kmita G, Wroblewska J, Whitelaw A. Jary S, et al. Among authors: whitelaw a. Arch Dis Child. 2012 Nov;97(11):955-9. doi: 10.1136/archdischild-2012-301778. Epub 2012 Aug 31. Arch Dis Child. 2012. PMID: 22941857
BACKGROUND: Infants with post-haemorrhagic ventricular dilatation (PHVD) have a high risk of severe disability and parenchymal infarction increases this risk. ...Infants who ultimately required a VP shunt had a significantly larger intraventricular echodensit …
BACKGROUND: Infants with post-haemorrhagic ventricular dilatation (PHVD) have a high risk of severe disability and parenchymal infarc …
Impaired brain growth and neurodevelopment in preterm infants with posthaemorrhagic ventricular dilatation.
Jary S, De Carli A, Ramenghi LA, Whitelaw A. Jary S, et al. Among authors: whitelaw a. Acta Paediatr. 2012 Jul;101(7):743-8. doi: 10.1111/j.1651-2227.2012.02686.x. Epub 2012 Apr 28. Acta Paediatr. 2012. PMID: 22452585
Total and regional brain volumes were calculated using a manual segmentation technique. Bayley Scales of Infant Development II were assessed at 2 years post-term. ...Volumetric measurements at term of total cerebral and cerebellar volume may have a role in predictin …
Total and regional brain volumes were calculated using a manual segmentation technique. Bayley Scales of Infant Development II were a …
Management of posthaemorrhagic ventricular dilatation.
Whitelaw A, Aquilina K. Whitelaw A, et al. Arch Dis Child Fetal Neonatal Ed. 2012 May;97(3):F229-3. doi: 10.1136/adc.2010.190173. Epub 2011 Feb 2. Arch Dis Child Fetal Neonatal Ed. 2012. PMID: 21289015 Review.
Reduction of cerebrospinal fluid production by acetazolamide and frusemide in a large multicentre randomised trial showed a worse outcome in the treated arm. A trial of drainage, irrigation and fibrinolytic therapy did not demonstrate a reduced need fo …
Reduction of cerebrospinal fluid production by acetazolamide and frusemide in a large multicentre randomised trial showed a wo …
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