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64 results
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Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.
Bersten DC, Bruning JB, Peet DJ, Whitelaw ML. Bersten DC, et al. Among authors: whitelaw ml. PLoS One. 2014 Jan 17;9(1):e85768. doi: 10.1371/journal.pone.0085768. eCollection 2014. PLoS One. 2014. PMID: 24465693 Free PMC article.
Rare variants in single-minded 1 (SIM1) are associated with severe obesity.
Ramachandrappa S, Raimondo A, Cali AM, Keogh JM, Henning E, Saeed S, Thompson A, Garg S, Bochukova EG, Brage S, Trowse V, Wheeler E, Sullivan AE, Dattani M, Clayton PE, Datta V, Bruning JB, Wareham NJ, O'Rahilly S, Peet DJ, Barroso I, Whitelaw ML, Farooqi IS. Ramachandrappa S, et al. Among authors: whitelaw ml. J Clin Invest. 2013 Jul;123(7):3042-50. doi: 10.1172/JCI68016. Epub 2013 Jun 17. J Clin Invest. 2013. PMID: 23778139 Free PMC article.
Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety.
Moir L, Bochukova EG, Dumbell R, Banks G, Bains RS, Nolan PM, Scudamore C, Simon M, Watson KA, Keogh J, Henning E, Hendricks A, O'Rahilly S, Barroso I; UK10K consortium, Sullivan AE, Bersten DC, Whitelaw ML, Kirsch S, Bentley E, Farooqi IS, Cox RD. Moir L, et al. Among authors: whitelaw ml. Mol Metab. 2017 Nov;6(11):1419-1428. doi: 10.1016/j.molmet.2017.08.006. Epub 2017 Aug 24. Mol Metab. 2017. PMID: 29107289 Free PMC article.
MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors.
Sullivan AE, Peet DJ, Whitelaw ML. Sullivan AE, et al. Among authors: whitelaw ml. FEBS J. 2016 Sep;283(18):3488-502. doi: 10.1111/febs.13824. Epub 2016 Aug 18. FEBS J. 2016. PMID: 27472814 Free article.
Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.
Sullivan AE, Raimondo A, Schwab TA, Bruning JB, Froguel P, Farooqi IS, Peet DJ, Whitelaw ML. Sullivan AE, et al. Among authors: whitelaw ml. Biochem J. 2014 Aug 1;461(3):403-12. doi: 10.1042/BJ20131618. Biochem J. 2014. PMID: 24814368
bHLH-PAS proteins in cancer.
Bersten DC, Sullivan AE, Peet DJ, Whitelaw ML. Bersten DC, et al. Among authors: whitelaw ml. Nat Rev Cancer. 2013 Dec;13(12):827-41. doi: 10.1038/nrc3621. Nat Rev Cancer. 2013. PMID: 24263188 Review.
The emerging roles of AhR in physiology and immunity.
Hao N, Whitelaw ML. Hao N, et al. Among authors: whitelaw ml. Biochem Pharmacol. 2013 Sep 1;86(5):561-70. doi: 10.1016/j.bcp.2013.07.004. Epub 2013 Jul 12. Biochem Pharmacol. 2013. PMID: 23856287
Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation.
Hao N, Bhakti VL, Peet DJ, Whitelaw ML. Hao N, et al. Among authors: whitelaw ml. Nucleic Acids Res. 2013 Jun;41(11):5626-38. doi: 10.1093/nar/gkt206. Epub 2013 Apr 17. Nucleic Acids Res. 2013. PMID: 23599003 Free PMC article.
Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling.
Hao N, Lee KL, Furness SG, Bosdotter C, Poellinger L, Whitelaw ML. Hao N, et al. Among authors: whitelaw ml. Mol Pharmacol. 2012 Dec;82(6):1082-93. doi: 10.1124/mol.112.078873. Epub 2012 Aug 30. Mol Pharmacol. 2012. PMID: 22936816
Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR.
Hao N, Whitelaw ML, Shearwin KE, Dodd IB, Chapman-Smith A. Hao N, et al. Among authors: whitelaw ml. Nucleic Acids Res. 2011 May;39(9):3695-709. doi: 10.1093/nar/gkq1336. Epub 2011 Jan 17. Nucleic Acids Res. 2011. PMID: 21245039 Free PMC article.
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