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Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies.
Kharasch ED, Whittington D, Hoffer C, Krudys K, Craig K, Vicini P, Sheffels P, Lalovic B. Kharasch ED, et al. Among authors: whittington d. Clin Pharmacokinet. 2005;44(7):731-51. doi: 10.2165/00003088-200544070-00005. Clin Pharmacokinet. 2005. PMID: 15966756 Clinical Trial.
Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir.
Kirby BJ, Collier AC, Kharasch ED, Dixit V, Desai P, Whittington D, Thummel KE, Unadkat JD. Kirby BJ, et al. Among authors: whittington d. Drug Metab Dispos. 2011 Dec;39(12):2329-37. doi: 10.1124/dmd.111.038646. Epub 2011 Sep 19. Drug Metab Dispos. 2011. PMID: 21930825 Free PMC article.
250 results