Whitworth AJ - Search Results

1

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.

Godena VK, Brookes-Hocking N, Moller A, Shaw G, Oswald M, Sancho RM, Miller CC, Whitworth AJ, De Vos KJ. Godena VK, et al. Among authors: whitworth aj. Nat Commun. 2014 Oct 15;5:5245. doi: 10.1038/ncomms6245. Nat Commun. 2014. PMID: 25316291 Free PMC article.

2

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

Tain LS, Mortiboys H, Tao RN, Ziviani E, Bandmann O, Whitworth AJ. Tain LS, et al. Among authors: whitworth aj. Nat Neurosci. 2009 Sep;12(9):1129-35. doi: 10.1038/nn.2372. Epub 2009 Aug 16. Nat Neurosci. 2009. PMID: 19684592 Free PMC article.

3

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.

Ziviani E, Tao RN, Whitworth AJ. Ziviani E, et al. Among authors: whitworth aj. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5018-23. doi: 10.1073/pnas.0913485107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194754 Free PMC article.

4

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.

Burchell VS, Nelson DE, Sanchez-Martinez A, Delgado-Camprubi M, Ivatt RM, Pogson JH, Randle SJ, Wray S, Lewis PA, Houlden H, Abramov AY, Hardy J, Wood NW, Whitworth AJ, Laman H, Plun-Favreau H. Burchell VS, et al. Among authors: whitworth aj. Nat Neurosci. 2013 Sep;16(9):1257-65. doi: 10.1038/nn.3489. Epub 2013 Aug 11. Nat Neurosci. 2013. PMID: 23933751 Free PMC article.

5

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy.

Ivatt RM, Sanchez-Martinez A, Godena VK, Brown S, Ziviani E, Whitworth AJ. Ivatt RM, et al. Among authors: whitworth aj. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8494-9. doi: 10.1073/pnas.1321207111. Epub 2014 May 27. Proc Natl Acad Sci U S A. 2014. PMID: 24912190 Free PMC article.

6

The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy.

Pogson JH, Ivatt RM, Sanchez-Martinez A, Tufi R, Wilson E, Mortiboys H, Whitworth AJ. Pogson JH, et al. Among authors: whitworth aj. PLoS Genet. 2014 Nov 20;10(11):e1004815. doi: 10.1371/journal.pgen.1004815. eCollection 2014 Nov. PLoS Genet. 2014. PMID: 25412178 Free PMC article.

7

VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin.

Malik BR, Godena VK, Whitworth AJ. Malik BR, et al. Among authors: whitworth aj. Hum Mol Genet. 2015 Nov 1;24(21):6106-17. doi: 10.1093/hmg/ddv322. Epub 2015 Aug 6. Hum Mol Genet. 2015. PMID: 26251041 Free PMC article.

8

Superoxide Dismutase (SOD)-mimetic M40403 Is Protective in Cell and Fly Models of Paraquat Toxicity: IMPLICATIONS FOR PARKINSON DISEASE.

Filograna R, Godena VK, Sanchez-Martinez A, Ferrari E, Casella L, Beltramini M, Bubacco L, Whitworth AJ, Bisaglia M. Filograna R, et al. Among authors: whitworth aj. J Biol Chem. 2016 Apr 22;291(17):9257-67. doi: 10.1074/jbc.M115.708057. Epub 2016 Mar 7. J Biol Chem. 2016. PMID: 26953346 Free PMC article.

9

Axonal transport defects are a common phenotype in Drosophila models of ALS.

Baldwin KR, Godena VK, Hewitt VL, Whitworth AJ. Baldwin KR, et al. Among authors: whitworth aj. Hum Mol Genet. 2016 Jun 15;25(12):2378-2392. doi: 10.1093/hmg/ddw105. Epub 2016 Apr 7. Hum Mol Genet. 2016. PMID: 27056981 Free PMC article.

10

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.

Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ, Kaspar BK, Meyer K, Shaw PJ, Grierson AJ, De Vos KJ. Webster CP, et al. Among authors: whitworth aj. EMBO J. 2016 Aug 1;35(15):1656-76. doi: 10.15252/embj.201694401. Epub 2016 Jun 22. EMBO J. 2016. PMID: 27334615 Free PMC article.

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