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Characterisation of the non-peptide nociceptin receptor agonist, Ro64-6198 in Chinese hamster ovary cells expressing recombinant human nociceptin receptors.
Hashiba E, Lambert DG, Jenck F, Wichmann J, Smith G. Hashiba E, et al. Among authors: wichmann j. Life Sci. 2002 Mar 1;70(15):1719-25. doi: 10.1016/s0024-3205(02)01477-7. Life Sci. 2002. PMID: 12002517
Influence of the selective ORL1 receptor agonist, Ro64-6198, on rodent neurological function.
Higgins GA, Grottick AJ, Ballard TM, Richards JG, Messer J, Takeshima H, Pauly-Evers M, Jenck F, Adam G, Wichmann J. Higgins GA, et al. Among authors: wichmann j. Neuropharmacology. 2001 Jul;41(1):97-107. doi: 10.1016/s0028-3908(01)00048-x. Neuropharmacology. 2001. PMID: 11445190
Accordingly, we have recently described a non-peptide agonist at the opioid receptor like (ORL1) receptor (1S,3aS)-8-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro64-6198; Jenck et al., PNAS 94 (2000) 4938; Wichmann et al., Eur. …
Accordingly, we have recently described a non-peptide agonist at the opioid receptor like (ORL1) receptor (1S,3aS)-8-(2,3,3a,4,5,6-hexahydro …
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
Jenck F, Wichmann J, Dautzenberg FM, Moreau JL, Ouagazzal AM, Martin JR, Lundstrom K, Cesura AM, Poli SM, Roever S, Kolczewski S, Adam G, Kilpatrick G. Jenck F, et al. Among authors: wichmann j. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4938-43. doi: 10.1073/pnas.090514397. Proc Natl Acad Sci U S A. 2000. PMID: 10758169 Free PMC article.
High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.
Röver S, Adam G, Cesura AM, Galley G, Jenck F, Monsma FJ Jr, Wichmann J, Dautzenberg FM. Röver S, et al. Among authors: wichmann j. J Med Chem. 2000 Apr 6;43(7):1329-38. doi: 10.1021/jm991129q. J Med Chem. 2000. PMID: 10753470
The orphanin receptor agonist RO 64-6198 does not induce place conditioning in rats.
Le Pen G, Wichmann J, Moreau JL, Jenck F. Le Pen G, et al. Among authors: wichmann j. Neuroreport. 2002 Mar 25;13(4):451-4. doi: 10.1097/00001756-200203250-00018. Neuroreport. 2002. PMID: 11930159
Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: comparison to morphine.
Reiss D, Wichmann J, Tekeshima H, Kieffer BL, Ouagazzal AM. Reiss D, et al. Among authors: wichmann j. Eur J Pharmacol. 2008 Jan 28;579(1-3):141-8. doi: 10.1016/j.ejphar.2007.10.031. Epub 2007 Oct 25. Eur J Pharmacol. 2008. PMID: 18031727
Effects of Ro 64-6198 in nociceptin/orphanin FQ-sensitive isolated tissues.
Rizzi D, Bigoni R, Rizzi A, Jenck F, Wichmann J, Guerrini R, Regoli D, Calo G. Rizzi D, et al. Among authors: wichmann j. Naunyn Schmiedebergs Arch Pharmacol. 2001 May;363(5):551-5. doi: 10.1007/s002100100399. Naunyn Schmiedebergs Arch Pharmacol. 2001. PMID: 11383716
Pharmacological characterization of the novel nonpeptide orphanin FQ/nociceptin receptor agonist Ro 64-6198: rapid and reversible desensitization of the ORL1 receptor in vitro and lack of tolerance in vivo.
Dautzenberg FM, Wichmann J, Higelin J, Py-Lang G, Kratzeisen C, Malherbe P, Kilpatrick GJ, Jenck F. Dautzenberg FM, et al. Among authors: wichmann j. J Pharmacol Exp Ther. 2001 Aug;298(2):812-9. J Pharmacol Exp Ther. 2001. PMID: 11454946
Orphanin FQ/nociceptin but not Ro 65-6570 inhibits the expression of cocaine-induced conditioned place preference.
Kotlińska J, Wichmann J, Legowska A, Rolka K, Silberring J. Kotlińska J, et al. Among authors: wichmann j. Behav Pharmacol. 2002 May;13(3):229-35. doi: 10.1097/00008877-200205000-00006. Behav Pharmacol. 2002. PMID: 12122313
Reversal of stress- and CRF-induced anorexia in rats by the synthetic nociceptin/orphanin FQ receptor agonist, Ro 64-6198.
Ciccocioppo R, Biondini M, Antonelli L, Wichmann J, Jenck F, Massi M. Ciccocioppo R, et al. Among authors: wichmann j. Psychopharmacology (Berl). 2002 May;161(2):113-9. doi: 10.1007/s00213-002-1020-7. Epub 2002 Mar 22. Psychopharmacology (Berl). 2002. PMID: 11981590
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