Wicht KJ - Search Results

1

N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity.

Figueiras M, Coelho L, Wicht KJ, Santos SA, Lavrado J, Gut J, Rosenthal PJ, Nogueira F, Egan TJ, Moreira R, Paulo A. Figueiras M, et al. Among authors: wicht kj. Bioorg Med Chem. 2015 Apr 1;23(7):1530-9. doi: 10.1016/j.bmc.2015.02.007. Epub 2015 Feb 13. Bioorg Med Chem. 2015. PMID: 25725608

2

Synthesis and antimalarial testing of neocryptolepine analogues: addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines.

Lu WJ, Wicht KJ, Wang L, Imai K, Mei ZW, Kaiser M, El Sayed Iel T, Egan TJ, Inokuchi T. Lu WJ, et al. Among authors: wicht kj. Eur J Med Chem. 2013 Jun;64:498-511. doi: 10.1016/j.ejmech.2013.03.072. Epub 2013 Apr 15. Eur J Med Chem. 2013. PMID: 23685569

3

In vitro antimalarial activity, β-haematin inhibition and structure-activity relationships in a series of quinoline triazoles.

Joshi MC, Wicht KJ, Taylor D, Hunter R, Smith PJ, Egan TJ. Joshi MC, et al. Among authors: wicht kj. Eur J Med Chem. 2013 Nov;69:338-47. doi: 10.1016/j.ejmech.2013.08.046. Epub 2013 Sep 12. Eur J Med Chem. 2013. PMID: 24077524

4

Synthesis and in vitro testing of antimalarial activity of non-natural-type neocryptolepines: structure–activity relationship study of 2,11- and 9,11-disubstituted 6-methylindolo[2,3-b]quinolines.

Wang N, Wicht KJ, Wang L, Lu WJ, Misumi R, Wang MQ, El Gokha AA, Kaiser M, El Sayed Iel T, Egan TJ, Inokuchi T. Wang N, et al. Among authors: wicht kj. Chem Pharm Bull (Tokyo). 2013;61(12):1282-90. doi: 10.1248/cpb.c13-00639. Chem Pharm Bull (Tokyo). 2013. PMID: 24436959

5

Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11.

Wang N, Wicht KJ, Imai K, Wang MQ, Anh Ngoc T, Kiguchi R, Kaiser M, Egan TJ, Inokuchi T. Wang N, et al. Among authors: wicht kj. Bioorg Med Chem. 2014 May 1;22(9):2629-42. doi: 10.1016/j.bmc.2014.03.030. Epub 2014 Mar 26. Bioorg Med Chem. 2014. PMID: 24721829

6

Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity.

Raj R, Mehra V, Gut J, Rosenthal PJ, Wicht KJ, Egan TJ, Hopper M, Wrischnik LA, Land KM, Kumar V. Raj R, et al. Among authors: wicht kj. Eur J Med Chem. 2014 Sep 12;84:425-32. doi: 10.1016/j.ejmech.2014.07.048. Epub 2014 Jul 15. Eur J Med Chem. 2014. PMID: 25038484

7

Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strains.

Chugh M, Scheurer C, Sax S, Bilsland E, van Schalkwyk DA, Wicht KJ, Hofmann N, Sharma A, Bashyam S, Singh S, Oliver SG, Egan TJ, Malhotra P, Sutherland CJ, Beck HP, Wittlin S, Spangenberg T, Ding XC. Chugh M, et al. Among authors: wicht kj. Antimicrob Agents Chemother. 2015 Feb;59(2):1110-8. doi: 10.1128/AAC.03265-14. Epub 2014 Dec 8. Antimicrob Agents Chemother. 2015. PMID: 25487796 Free PMC article.

8

Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity.

Sandlin RD, Fong KY, Wicht KJ, Carrell HM, Egan TJ, Wright DW. Sandlin RD, et al. Among authors: wicht kj. Int J Parasitol Drugs Drug Resist. 2014 Sep 11;4(3):316-25. doi: 10.1016/j.ijpddr.2014.08.002. eCollection 2014 Dec. Int J Parasitol Drugs Drug Resist. 2014. PMID: 25516843 Free PMC article.

9

Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity.

Wicht KJ, Combrinck JM, Smith PJ, Egan TJ. Wicht KJ, et al. Bioorg Med Chem. 2015 Aug 15;23(16):5210-7. doi: 10.1016/j.bmc.2014.12.020. Epub 2014 Dec 20. Bioorg Med Chem. 2015. PMID: 25573118 Free PMC article.

10

Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.

Ongarora DS, Strydom N, Wicht K, Njoroge M, Wiesner L, Egan TJ, Wittlin S, Jurva U, Masimirembwa CM, Chibale K. Ongarora DS, et al. Bioorg Med Chem. 2015 Sep 1;23(17):5419-32. doi: 10.1016/j.bmc.2015.07.051. Epub 2015 Jul 30. Bioorg Med Chem. 2015. PMID: 26264839

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