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The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression.
Yu JH, Zhu BM, Wickre M, Riedlinger G, Chen W, Hosui A, Robinson GW, Hennighausen L. Yu JH, et al. Among authors: wickre m. Hepatology. 2010 Nov;52(5):1808-18. doi: 10.1002/hep.23882. Hepatology. 2010. PMID: 21038417 Free PMC article.
The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.
Kimura A, Rieger MA, Simone JM, Chen W, Wickre MC, Zhu BM, Hoppe PS, O'Shea JJ, Schroeder T, Hennighausen L. Kimura A, et al. Among authors: wickre mc. Blood. 2009 Nov 19;114(21):4721-8. doi: 10.1182/blood-2009-04-216390. Epub 2009 Sep 24. Blood. 2009. PMID: 19779039 Free PMC article.
Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia.
Hoelbl A, Schuster C, Kovacic B, Zhu B, Wickre M, Hoelzl MA, Fajmann S, Grebien F, Warsch W, Stengl G, Hennighausen L, Poli V, Beug H, Moriggl R, Sexl V. Hoelbl A, et al. Among authors: wickre m. EMBO Mol Med. 2010 Mar;2(3):98-110. doi: 10.1002/emmm.201000062. EMBO Mol Med. 2010. PMID: 20201032 Free PMC article.