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From chemical tools to clinical medicines: nonimmunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds.
Sweeney ZK, Fu J, Wiedmann B. Sweeney ZK, et al. Among authors: wiedmann b. J Med Chem. 2014 Sep 11;57(17):7145-59. doi: 10.1021/jm500223x. Epub 2014 Jun 3. J Med Chem. 2014. PMID: 24831536
Anti-hepatitis C virus activity and toxicity of type III phosphatidylinositol-4-kinase beta inhibitors.
Lamarche MJ, Borawski J, Bose A, Capacci-Daniel C, Colvin R, Dennehy M, Ding J, Dobler M, Drumm J, Gaither LA, Gao J, Jiang X, Lin K, McKeever U, Puyang X, Raman P, Thohan S, Tommasi R, Wagner K, Xiong X, Zabawa T, Zhu S, Wiedmann B. Lamarche MJ, et al. Among authors: wiedmann b. Antimicrob Agents Chemother. 2012 Oct;56(10):5149-56. doi: 10.1128/AAC.00946-12. Epub 2012 Jul 23. Antimicrob Agents Chemother. 2012. PMID: 22825118 Free PMC article.
Multiple cyclophilins involved in different cellular pathways mediate HCV replication.
Gaither LA, Borawski J, Anderson LJ, Balabanis KA, Devay P, Joberty G, Rau C, Schirle M, Bouwmeester T, Mickanin C, Zhao S, Vickers C, Lee L, Deng G, Baryza J, Fujimoto RA, Lin K, Compton T, Wiedmann B. Gaither LA, et al. Among authors: wiedmann b. Virology. 2010 Feb 5;397(1):43-55. doi: 10.1016/j.virol.2009.10.043. Epub 2009 Nov 24. Virology. 2010. PMID: 19932913 Free article.
Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.
Borawski J, Troke P, Puyang X, Gibaja V, Zhao S, Mickanin C, Leighton-Davies J, Wilson CJ, Myer V, Cornellataracido I, Baryza J, Tallarico J, Joberty G, Bantscheff M, Schirle M, Bouwmeester T, Mathy JE, Lin K, Compton T, Labow M, Wiedmann B, Gaither LA. Borawski J, et al. Among authors: wiedmann b. J Virol. 2009 Oct;83(19):10058-74. doi: 10.1128/JVI.02418-08. Epub 2009 Jul 15. J Virol. 2009. PMID: 19605471 Free PMC article.
A Diacylglycerol Transferase 1 Inhibitor Is a Potent Hepatitis C Antiviral in Vitro but Not in Patients in a Randomized Clinical Trial.
Gane E, Stedman C, Dole K, Chen J, Meyers CD, Wiedmann B, Zhang J, Raman P, Colvin RA. Gane E, et al. Among authors: wiedmann b. ACS Infect Dis. 2017 Feb 10;3(2):144-151. doi: 10.1021/acsinfecdis.6b00138. Epub 2016 Nov 8. ACS Infect Dis. 2017. PMID: 27788579 Clinical Trial.
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
Fu J, Tjandra M, Becker C, Bednarczyk D, Capparelli M, Elling R, Hanna I, Fujimoto R, Furegati M, Karur S, Kasprzyk T, Knapp M, Leung K, Li X, Lu P, Mergo W, Miault C, Ng S, Parker D, Peng Y, Roggo S, Rivkin A, Simmons RL, Wang M, Wiedmann B, Weiss AH, Xiao L, Xie L, Xu W, Yifru A, Yang S, Zhou B, Sweeney ZK. Fu J, et al. Among authors: wiedmann b. J Med Chem. 2014 Oct 23;57(20):8503-16. doi: 10.1021/jm500862r. Epub 2014 Oct 13. J Med Chem. 2014. PMID: 25310383
2-Alkyloxazoles as potent and selective PI4KIII╬▓ inhibitors demonstrating inhibition of HCV replication.
Keaney EP, Connolly M, Dobler M, Karki R, Honda A, Sokup S, Karur S, Britt S, Patnaik A, Raman P, Hamann LG, Wiedmann B, LaMarche MJ. Keaney EP, et al. Among authors: wiedmann b. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3714-8. doi: 10.1016/j.bmcl.2014.07.015. Epub 2014 Jul 12. Bioorg Med Chem Lett. 2014. PMID: 25065492
Mechanism of resistance of hepatitis C virus replicons to structurally distinct cyclophilin inhibitors.
Puyang X, Poulin DL, Mathy JE, Anderson LJ, Ma S, Fang Z, Zhu S, Lin K, Fujimoto R, Compton T, Wiedmann B. Puyang X, et al. Among authors: wiedmann b. Antimicrob Agents Chemother. 2010 May;54(5):1981-7. doi: 10.1128/AAC.01236-09. Epub 2010 Feb 22. Antimicrob Agents Chemother. 2010. PMID: 20176894 Free PMC article.
Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion.
Anderson LJ, Lin K, Compton T, Wiedmann B. Anderson LJ, et al. Among authors: wiedmann b. Virol J. 2011 Jun 28;8:329. doi: 10.1186/1743-422X-8-329. Virol J. 2011. PMID: 21711559 Free PMC article.
Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.
Dean CR, Narayan S, Richards J, Daigle DM, Esterow S, Leeds JA, Kamp H, Puyang X, Wiedmann B, Mueller D, Voshol H, van Oostrum J, Wall D, Koehn J, Dzink-Fox J, Ryder NS. Dean CR, et al. Among authors: wiedmann b. Antimicrob Agents Chemother. 2007 Mar;51(3):1004-10. doi: 10.1128/AAC.01103-06. Epub 2007 Jan 12. Antimicrob Agents Chemother. 2007. PMID: 17220413 Free PMC article.
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