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Detection of ubiquitinated huntingtin species in intracellular aggregates.
Juenemann K, Wiemhoefer A, Reits EA. Juenemann K, et al. Among authors: wiemhoefer a. Front Mol Neurosci. 2015 Jan 28;8:1. doi: 10.3389/fnmol.2015.00001. eCollection 2015. Front Mol Neurosci. 2015. PMID: 25674046 Free PMC article.
Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies.
Schipper-Krom S, Juenemann K, Jansen AH, Wiemhoefer A, van den Nieuwendijk R, Smith DL, Hink MA, Bates GP, Overkleeft H, Ovaa H, Reits E. Schipper-Krom S, et al. Among authors: wiemhoefer a. FEBS Lett. 2014 Jan 3;588(1):151-9. doi: 10.1016/j.febslet.2013.11.023. Epub 2013 Nov 26. FEBS Lett. 2014. PMID: 24291262 Free article.
Reduced amyloid-β degradation in early Alzheimer's disease but not in the APPswePS1dE9 and 3xTg-AD mouse models.
Stargardt A, Gillis J, Kamphuis W, Wiemhoefer A, Kooijman L, Raspe M, Benckhuijsen W, Drijfhout JW, Hol EM, Reits E. Stargardt A, et al. Among authors: wiemhoefer a. Aging Cell. 2013 Jun;12(3):499-507. doi: 10.1111/acel.12074. Epub 2013 Apr 23. Aging Cell. 2013. PMID: 23534431 Free article.
Expanded polyglutamine-containing N-terminal huntingtin fragments are entirely degraded by mammalian proteasomes.
Juenemann K, Schipper-Krom S, Wiemhoefer A, Kloss A, Sanz Sanz A, Reits EA. Juenemann K, et al. Among authors: wiemhoefer a. J Biol Chem. 2013 Sep 20;288(38):27068-84. doi: 10.1074/jbc.M113.486076. Epub 2013 Aug 1. J Biol Chem. 2013. PMID: 23908352 Free PMC article.
Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2.
Wiemhoefer A, Stargardt A, van der Linden WA, Renner MC, van Kesteren RE, Stap J, Raspe MA, Tomkinson B, Kessels HW, Ovaa H, Overkleeft HS, Florea B, Reits EA. Wiemhoefer A, et al. Mol Cell Proteomics. 2015 Aug;14(8):2177-93. doi: 10.1074/mcp.M114.043331. Epub 2015 Jun 3. Mol Cell Proteomics. 2015. PMID: 26041847 Free PMC article.