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Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.
Wiesmann C, Ultsch MH, Bass SH, de Vos AM. Wiesmann C, et al. Nature. 1999 Sep 9;401(6749):184-8. doi: 10.1038/43705. Nature. 1999. PMID: 10490030
Cryo-EM in drug discovery: achievements, limitations and prospects.
Renaud JP, Chari A, Ciferri C, Liu WT, Rémigy HW, Stark H, Wiesmann C. Renaud JP, et al. Among authors: wiesmann c. Nat Rev Drug Discov. 2018 Jul;17(7):471-492. doi: 10.1038/nrd.2018.77. Epub 2018 Jun 8. Nat Rev Drug Discov. 2018. PMID: 29880918 Review.
A structural portrait of the PDZ domain family.
Ernst A, Appleton BA, Ivarsson Y, Zhang Y, Gfeller D, Wiesmann C, Sidhu SS. Ernst A, et al. Among authors: wiesmann c. J Mol Biol. 2014 Oct 23;426(21):3509-19. doi: 10.1016/j.jmb.2014.08.012. Epub 2014 Aug 23. J Mol Biol. 2014. PMID: 25158098
Design of synthetic autonomous VH domain libraries and structural analysis of a VH domain bound to vascular endothelial growth factor.
Ma X, Barthelemy PA, Rouge L, Wiesmann C, Sidhu SS. Ma X, et al. Among authors: wiesmann c. J Mol Biol. 2013 Jun 26;425(12):2247-59. doi: 10.1016/j.jmb.2013.03.020. Epub 2013 Mar 16. J Mol Biol. 2013. PMID: 23507309
Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.
Hatzivassiliou G, Haling JR, Chen H, Song K, Price S, Heald R, Hewitt JF, Zak M, Peck A, Orr C, Merchant M, Hoeflich KP, Chan J, Luoh SM, Anderson DJ, Ludlam MJ, Wiesmann C, Ultsch M, Friedman LS, Malek S, Belvin M. Hatzivassiliou G, et al. Among authors: wiesmann c. Nature. 2013 Sep 12;501(7466):232-6. doi: 10.1038/nature12441. Epub 2013 Aug 11. Nature. 2013. PMID: 23934108
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.
Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM. Wertz IE, et al. Among authors: wiesmann c. Nature. 2004 Aug 5;430(7000):694-9. doi: 10.1038/nature02794. Epub 2004 Jul 18. Nature. 2004. PMID: 15258597
Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Wiesmann C, Katschke KJ, Yin J, Helmy KY, Steffek M, Fairbrother WJ, McCallum SA, Embuscado L, DeForge L, Hass PE, van Lookeren Campagne M. Wiesmann C, et al. Nature. 2006 Nov 9;444(7116):217-20. doi: 10.1038/nature05263. Epub 2006 Oct 15. Nature. 2006. PMID: 17051150
Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design.
Choong IC, Lew W, Lee D, Pham P, Burdett MT, Lam JW, Wiesmann C, Luong TN, Fahr B, DeLano WL, McDowell RS, Allen DA, Erlanson DA, Gordon EM, O'Brien T. Choong IC, et al. Among authors: wiesmann c. J Med Chem. 2002 Nov 7;45(23):5005-22. doi: 10.1021/jm020230j. J Med Chem. 2002. PMID: 12408711
In situ assembly of enzyme inhibitors using extended tethering.
Erlanson DA, Lam JW, Wiesmann C, Luong TN, Simmons RL, DeLano WL, Choong IC, Burdett MT, Flanagan WM, Lee D, Gordon EM, O'Brien T. Erlanson DA, et al. Among authors: wiesmann c. Nat Biotechnol. 2003 Mar;21(3):308-14. doi: 10.1038/nbt786. Epub 2003 Feb 3. Nat Biotechnol. 2003. PMID: 12563278
Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering.
Stengel KF, Harden-Bowles K, Yu X, Rouge L, Yin J, Comps-Agrar L, Wiesmann C, Bazan JF, Eaton DL, Grogan JL. Stengel KF, et al. Among authors: wiesmann c. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5399-404. doi: 10.1073/pnas.1120606109. Epub 2012 Mar 15. Proc Natl Acad Sci U S A. 2012. PMID: 22421438 Free PMC article.
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