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Specialized hepatocyte-like cells regulate Drosophila lipid metabolism.

Gutierrez E, Wiggins D, Fielding B, Gould AP. Gutierrez E, et al. Among authors: wiggins d. Nature. 2007 Jan 18;445(7125):275-80. doi: 10.1038/nature05382. Epub 2006 Nov 29. Nature. 2007. PMID: 17136098

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Inhibition of hepatocyte lipogenesis by nitric oxide donor: could nitric oxide regulate lipid synthesis?

Roediger WE, Hems R, Wiggins D, Gibbons GF. Roediger WE, et al. Among authors: wiggins d. IUBMB Life. 2004 Jan;56(1):35-40. doi: 10.1080/15216540310001649822. IUBMB Life. 2004. PMID: 14992378

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Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis.

Lelliott CJ, López M, Curtis RK, Parker N, Laudes M, Yeo G, Jimenez-Liñan M, Grosse J, Saha AK, Wiggins D, Hauton D, Brand MD, O'Rahilly S, Griffin JL, Gibbons GF, Vidal-Puig A. Lelliott CJ, et al. Among authors: wiggins d. FASEB J. 2005 Jul;19(9):1108-19. doi: 10.1096/fj.04-3196com. FASEB J. 2005. PMID: 15985534

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Manipulation of cholesterol and cholesteryl ester synthesis has multiple effects on the metabolism of apolipoprotein B and the secretion of very-low-density lipoprotein by primary hepatocyte cultures.

Brown A, Wiggins D, Gibbons GF. Brown A, et al. Among authors: wiggins d. Biochim Biophys Acta. 1999 Sep 22;1440(2-3):253-65. doi: 10.1016/s1388-1981(99)00133-x. Biochim Biophys Acta. 1999. PMID: 10521709

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Chelating agents and rat liver mitochondria.

Lund P, Wiggins D. Lund P, et al. Among authors: wiggins d. Biochim Biophys Acta. 1989 Aug 3;975(3):330-5. doi: 10.1016/s0005-2728(89)80340-8. Biochim Biophys Acta. 1989. PMID: 2503035

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A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver.

Knight BL, Hebbachi A, Hauton D, Brown AM, Wiggins D, Patel DD, Gibbons GF. Knight BL, et al. Among authors: wiggins d. Biochem J. 2005 Jul 15;389(Pt 2):413-21. doi: 10.1042/BJ20041896. Biochem J. 2005. PMID: 15777286 Free PMC article.

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Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice.

Patel DD, Knight BL, Wiggins D, Humphreys SM, Gibbons GF. Patel DD, et al. Among authors: wiggins d. J Lipid Res. 2001 Mar;42(3):328-37. J Lipid Res. 2001. PMID: 11254743

The results suggest that PPAR alpha-deficiency disturbs the normal circadian regulation of certain SREBP-sensitive genes in the liver, but does not affect their response to dietary cholesterol. -- Patel, D. D., B. L. Knight, D. Wiggins, S. M. Humphreys …

The results suggest that PPAR alpha-deficiency disturbs the normal circadian regulation of certain SREBP-sensitive genes in the liver, but d …

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The roles of insulin and fatty acids in the regulation of hepatic very-low-density lipoprotein assembly.

Gibbons GF, Brown AM, Wiggins D, Pease R. Gibbons GF, et al. Among authors: wiggins d. J R Soc Med. 2002;95 Suppl 42(Suppl 42):23-32. J R Soc Med. 2002. PMID: 12216323 Free PMC article. Review. No abstract available.

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PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery.

Ramracheya RD, McCulloch LJ, Clark A, Wiggins D, Johannessen H, Olsen MK, Cai X, Zhao CM, Chen D, Rorsman P. Ramracheya RD, et al. Among authors: wiggins d. Cell Rep. 2016 May 3;15(5):944-950. doi: 10.1016/j.celrep.2016.03.091. Epub 2016 Apr 21. Cell Rep. 2016. PMID: 27117413 Free PMC article.

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Metabolic characteristics of a human hepatoma cell line stably transfected with hormone-sensitive lipase.

Pease RJ, Wiggins D, Saggerson ED, Tree J, Gibbons GF. Pease RJ, et al. Among authors: wiggins d. Biochem J. 1999 Jul 15;341 ( Pt 2)(Pt 2):453-60. Biochem J. 1999. PMID: 10393105 Free PMC article.

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