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Accelerometer-based analyses of animal sleep patterns.
Watanabe YY, Rutz C. Watanabe YY, et al. Elife. 2022 Mar 8;11:e77349. doi: 10.7554/eLife.77349. Elife. 2022. PMID: 35258454 Free PMC article.
Body-motion sensors can be used to study non-invasively how animals sleep in the wild, opening up exciting opportunities for comparative analyses across species....
Body-motion sensors can be used to study non-invasively how animals sleep in the wild, opening up exciting opportunities for comparat …
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice.
Abdel-Haq R, Schlachetzki JCM, Boktor JC, Cantu-Jungles TM, Thron T, Zhang M, Bostick JW, Khazaei T, Chilakala S, Morais LH, Humphrey G, Keshavarzian A, Katz JE, Thomson M, Knight R, Gradinaru V, Hamaker BR, Glass CK, Mazmanian SK. Abdel-Haq R, et al. Elife. 2022 Nov 8;11:e81453. doi: 10.7554/eLife.81453. Elife. 2022. PMID: 36346385 Free PMC article.
Single-cell RNA-seq analysis of microglia from the substantia nigra and striatum uncovers increased pro-inflammatory signaling and reduced homeostatic responses in ASO mice compared to wild-type counterparts on standard diets. However, prebiotic feeding reverses pathogenic …
Single-cell RNA-seq analysis of microglia from the substantia nigra and striatum uncovers increased pro-inflammatory signaling and reduced h …
Epac2 in midbrain dopamine neurons contributes to cocaine reinforcement via enhancement of dopamine release.
Liu X, Vickstrom CR, Yu H, Liu S, Snarrenberg ST, Friedman V, Mu L, Chen B, Kelly TJ, Baker DA, Liu QS. Liu X, et al. Elife. 2022 Aug 22;11:e80747. doi: 10.7554/eLife.80747. Elife. 2022. PMID: 35993549 Free PMC article.
Conversely, chemogenetic inhibition of VTA dopamine neurons with Gi-DREADD reduced dopamine release and cocaine self-administration in wild-type mice. Epac2-mediated enhancement of dopamine release may therefore represent a novel and powerful mechanism that contributes to …
Conversely, chemogenetic inhibition of VTA dopamine neurons with Gi-DREADD reduced dopamine release and cocaine self-administration in wi …
Variable paralog expression underlies phenotype variation.
Bailon-Zambrano R, Sucharov J, Mumme-Monheit A, Murry M, Stenzel A, Pulvino AT, Mitchell JM, Colborn KL, Nichols JT. Bailon-Zambrano R, et al. Elife. 2022 Sep 22;11:e79247. doi: 10.7554/eLife.79247. Elife. 2022. PMID: 36134886 Free PMC article.
We found that mef2ca paralog expression is variable in unselected wild-type zebrafish, motivating the hypothesis that heritable variation in paralog expression underlies mutant phenotype severity and variation. ...
We found that mef2ca paralog expression is variable in unselected wild-type zebrafish, motivating the hypothesis that heritable varia …
Primate malarias as a model for cross-species parasite transmission.
Voinson M, Nunn CL, Goldberg A. Voinson M, et al. Elife. 2022 Jan 28;11:e69628. doi: 10.7554/eLife.69628. Elife. 2022. PMID: 35086643 Free PMC article. Review.
Plasmodium host switching from nonhuman primates to humans led to ancient introductions of the most common malaria-causing agents in humans today, and new parasite switching is a growing threat, especially in Asia and South America. Based on a wild host-Plasmodium occurren …
Plasmodium host switching from nonhuman primates to humans led to ancient introductions of the most common malaria-causing agents in humans …
Lessons from a catalogue of 6674 brain recordings.
Makin ADJ, Tyson-Carr J, Rampone G, Derpsch Y, Wright D, Bertamini M. Makin ADJ, et al. Elife. 2022 Jun 15;11:e66388. doi: 10.7554/eLife.66388. Elife. 2022. PMID: 35703370 Free PMC article.
The evolution of manipulative cheating.
Liu M, West SA, Wild G. Liu M, et al. Elife. 2022 Oct 4;11:e80611. doi: 10.7554/eLife.80611. Elife. 2022. PMID: 36193888 Free PMC article.
Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration.
Jiang FQ, Liu K, Chen JX, Cao Y, Chen WY, Zhao WL, Song GH, Liang CQ, Zhou YM, Huang HL, Huang RJ, Zhao H, Park KS, Ju Z, Cai D, Qi XF. Jiang FQ, et al. Elife. 2022 Nov 18;11:e77014. doi: 10.7554/eLife.77014. Elife. 2022. PMID: 36399125 Free PMC article.
However, the overexpression of deltaFgf16, in which the m(6)A consensus sequence was mutated, significantly increased cardiomyocyte proliferation and accelerated heart regeneration in postnatal mice compared with wild-type Fgf16. Our data demonstrate that Mettl3 post-trans …
However, the overexpression of deltaFgf16, in which the m(6)A consensus sequence was mutated, significantly increased cardiomyocyte prolifer …
Contingency and selection in mitochondrial genome dynamics.
Nunn CJ, Goyal S. Nunn CJ, et al. Elife. 2022 Apr 11;11:e76557. doi: 10.7554/eLife.76557. Elife. 2022. PMID: 35404229 Free PMC article.
This model has numerous advantages over mammalian systems due to its much larger mtDNA and ease of artificially competing mutant and wild-type mtDNA copies in cells. We show a previously unseen pattern that constrains subsequent excision events in mtDNA fragmentation in ye …
This model has numerous advantages over mammalian systems due to its much larger mtDNA and ease of artificially competing mutant and wild …
Prefrontal-amygdalar oscillations related to social behavior in mice.
Kuga N, Abe R, Takano K, Ikegaya Y, Sasaki T. Kuga N, et al. Elife. 2022 May 17;11:e78428. doi: 10.7554/eLife.78428. Elife. 2022. PMID: 35580019 Free PMC article.
We recorded local field potentials (LFPs) from the dorsal medial prefrontal cortex (dmPFC) and basolateral amygdala (BLA) while male mice engaged on social behavior. We found that in wild-type mice, both the dmPFC and BLA increased 4-7 Hz oscillation power and decreased 30 …
We recorded local field potentials (LFPs) from the dorsal medial prefrontal cortex (dmPFC) and basolateral amygdala (BLA) while male mice en …
86 results